The (TAAAA)n microsatellite polymorphism in the SHBG gene influences serum SHBG levels in women with polycystic ovary syndrome
The (TAAAA)n microsatellite polymorphism in the SHBG gene influences serum SHBG levels in women with polycystic ovary syndrome
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DOI：
10.1093/humrep/del457
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发表时间：
2007-04-01
影响因子：
6.1
通讯作者：
Gersak, Ksenija
中科院分区：
文献类型：
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作者：
Ferk, Polonca;Teran, Natasa;Gersak, Ksenija
高雄激素血症是多囊卵巢综合征（PCOS）的常见特征。性激素结合球蛋白（SHBG）基因被认为是PCOS的候选基因。研究了SHBG基因微卫星多态性（TAAAA）（n）对PCOS患者血清SHBG水平的可能影响。方法：123例PCOS患者和110例年龄匹配的对照者被纳入研究。采集外周血样本。对SHBG基因的（TAAAA）（n）多态性进行基因分型。测定血清LH、FSH、SHBG和总睾酮浓度。研究结果：结果发现，PCOS患者中SHBG等位基因的频率均未高于对照组，但TAAAA重复数为6-11个。PCOS患者血清SHBG水平显著低于对照组（P <0.001），并且发现（TAAAA）（n）SHBG多态性对PCOS患者（55.3%）和对照组（33.1%）的SHBG水平有很大影响。结论：（TAAAA）（n）SHBG基因多态性可能是血清SHBG水平的重要预测因子，因此，PCOS高雄激素血症的临床表现。
Hyperandrogenaemia is a common feature of polycystic ovary syndrome (PCOS). The sex hormone-binding globulin (SHBG) gene was proposed as being a PCOS candidate gene. A possible influence of the microsatellite polymorphism (TAAAA)(n) in the SHBG gene on serum SHBG levels in PCOS patients was investigated. METHODS: One hundred and twenty-three PCOS patients and 110 age-matched controls were included in the study. Peripheral blood samples were obtained. Genotyping of the (TAAAA)(n) polymorphism in the SHBG gene was performed. Serum LH, FSH, SHBG and total testosterone concentrations were determined. RESULTS: SHBG alleles with 6-11 TAAAA repeats were found. None of the SHBG alleles or genotypes were present at a significantly more frequent rate in PCOS patients compared with controls. Serum SHBG levels were significantly lower (P < 0.001) in PCOS patients compared with controls and were found to be strongly influenced by the (TAAAA)(n) SHBG polymorphism, in both the PCOS (55.3 %) and control (33.1 %) groups of patients. CONCLUSIONS: The (TAAAA)(n) SHBG gene polymorphism might be an important predictor for serum SHBG levels and, consequently, for hyperandrogenaemic clinical presentation of PCOS.