Cyclosporin A: alterations of the cellular immune response in S-antigen-induced experimental autoimmune uveitis.
Cyclosporin A: alterations of the cellular immune response in S-antigen-induced experimental autoimmune uveitis.
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环孢素 A：S 抗原诱导的实验性自身免疫性葡萄膜炎中细胞免疫反应的改变。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
I. Gery
中科院分区：
文献类型：
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作者：
R. Nussenblatt;M. Salinas;B. Waksman;I. Gery
我们以前已经表明，环孢菌素A（CsA）是有效的预防S-抗原（S-Ag）诱导的实验性自身免疫性葡萄膜炎（EAU）。刘易斯大鼠，很容易发展EAU，研究了细胞介导的免疫功能的变化与CsA治疗。与未保护组相比，CsA治疗组动物引流S-Ag免疫部位的淋巴结显著较小（p <0.01），与对照组相比，也显示出深刻的组织学变化。淋巴结和外周血淋巴细胞的体外反应在CsA处理的动物中大大减少。CsA处理的大鼠血清也能够抑制体外增殖反应。这些发现表明，CsA处理的刘易斯大鼠在几个细胞介导的免疫功能的改变，从而不允许充分发展的免疫事件，最终导致葡萄膜炎。
We have previously shown that Cyclosporin A (CsA) is effective in preventing S-antigen (S-Ag)-induced experimental autoimmune uveitis (EAU). Lewis rats, which readily develop EAU, were studied for the alterations in cell-mediated immune functions associated with CsA therapy. Lymph nodes draining the site of S-Ag immunization were significantly smaller in the CsA-treated animals when compared to the nonprotected group (p less than 0.01), and also showed profound histologic alterations when compared to controls. In vitro responses of lymphocytes from lymph node and peripheral blood were greatly diminished in the CsA-treated animals. Sera from rats treated with CsA also were capable of inhibiting in vitro proliferative responses. These findings demonstrate that CsA-treated Lewis rats have alterations in several cell-mediated immune functions, thereby not permitting full development of the immune events that ultimately lead to uveitis.