Regulation of calcium signalling by adenine-based second messengers
Regulation of calcium signalling by adenine-based second messengers
复制标题
DOI：
10.1042/bst0350109
复制
发表时间：
2007-02-01
影响因子：
3.9
通讯作者：
Guse, A. H.
中科院分区：
文献类型：
--
作者：
Fliegert, R.;Gasser, A.;Guse, A. H.
cADPR [环状ADPR（ADP-核糖）]、NAADP（烟酸-腺嘌呤二核苷酸磷酸）和ADPR属于含腺嘌呤的第二信使家族。它们是代谢相关的，并且都参与细胞Ca 2+稳态的调节。特异性质膜受体的激活与许多细胞类型和组织中的cADPR形成有关。相反，受体介导的NAADP和ADPR的形成仅在少数选定的细胞系统中显示。由cADPR触发的细胞内Ca 2+通道是RyR？（ryanodine受体）;在NAADP的情况下，已经提出了RyR和新的Ca 2+通道的激活。相反，ADPR打开属于TRIP离子通道家族的非特异性阳离子通道TRPM 2 [TRP（瞬时受体电位）melastatin 2]。
cADPR [cyclic ADPR (ADP-ribose)], NAADP (nicotinic acid-adenine dinucleotide phosphate) and ADPR belong to the family of adenine-containing second messengers. They are metabolically related and are all involved in the regulation of cellular Ca2+ homoeostasis. Activation of specific plasma membrane receptors is connected to cADPR formation in many cell types and tissues. in contrast receptor-mediated formation of NAADP and ADPR has been shown only in a few selected cellular systems. The intracellular Ca2+ channel triggered by cADPR is the RyR? (ryanodine receptor); in the case of NAADP, both activation of RyR and a novel Ca2+ channel have been proposed. In contrast, ADPR opens the non-specific cation channel TRPM2 [TRP (transient receptor potential) melastatin 2] that belongs to the TRIP family of ion channels.