Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment.
Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment.
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癌细胞的肿瘤内异质性及其对癌症治疗的影响
DOI：
10.1038/aps.2015.92
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发表时间：
2015-10
影响因子：
8.2
通讯作者：
Yu Q
中科院分区：
文献类型：
--
作者：
Sun XX;Yu Q
最近的研究表明，在肿瘤的不同地理区域或肿瘤进展的不同阶段存在广泛的遗传和非遗传变异，这被称为肿瘤内异质性。导致这种现象的原因有几个，包括基因组不稳定性、表观遗传改变、可塑性基因表达、信号转导和微环境差异。这些变量可能会影响调节癌细胞生长的关键信号通路，驱动表型多样性，并对癌症治疗提出挑战。了解这种异质性的机制将有助于开发有效的治疗策略。
Recent studies have revealed extensive genetic and non-genetic variation across different geographical regions of a tumor or throughout different stages of tumor progression, which is referred to as intra-tumor heterogeneity. Several causes contribute to this phenomenon, including genomic instability, epigenetic alteration, plastic gene expression, signal transduction, and microenvironmental differences. These variables may affect key signaling pathways that regulate cancer cell growth, drive phenotypic diversity, and pose challenges to cancer treatment. Understanding the mechanisms underlying this heterogeneity will support the development of effective therapeutic strategies.