Intelligent design of multifunctional lipid-coated nanoparticle platforms for cancer therapy.
Intelligent design of multifunctional lipid-coated nanoparticle platforms for cancer therapy.
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DOI：
10.4155/tde.12.127
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发表时间：
2012-12
影响因子：
4.2
通讯作者：
Huang L
中科院分区：
文献类型：
--
作者：
Ramishetti S;Huang L
纳米技术正在迅速发展，并极大地改变了药物输送的范式。纳米粒子的小尺寸、独特的化学性质、大表面积、结构多样性和多功能性被证明对治疗癌症等众所周知的难以治疗的疾病非常有利。多功能纳米颗粒被设计用于通过被动或主动靶向来增强肿瘤的摄取，同时通过将PEG结合到表面来避免网状内皮系统的摄取。第一代纳米粒子系统，如脂质体，是药物和核酸治疗的良好载体，尽管它们有一些局限性。这些脂质双分子层现在被用作载药固体核心颗粒的优良载体，如氧化铁、介孔二氧化硅和磷酸钙。在本文中，讨论了它们的设计，以及它们在癌症治疗中的多功能作用。
Nanotechnology is rapidly evolving and dramatically changing the paradigms of drug delivery. The small sizes, unique chemical properties, large surface areas, structural diversity and multifunctionality of nanoparticles prove to be greatly advantageous for combating notoriously therapeutically evasive diseases such as cancer. Multifunctional nanoparticles have been designed to enhance tumor uptake through either passive or active targeting, while also avoiding reticuloendothelial system uptake through the incorporation of PEG onto the surface. First-generation nanoparticle systems, such as liposomes, are good carriers for drugs and nucleic acid therapeutics, although they have some limitations. These lipid bilayers are now being utilized as excellent carriers for drug-loaded, solid core particles such as iron oxide, mesoporus silica and calcium phosphate. In this article, their design, as well as their multifunctional role in cancer therapy are discussed.