Nitric Oxide and Pathogenic Mechanisms Involved in the Development of Vascular Diseases
Nitric Oxide and Pathogenic Mechanisms Involved in the Development of Vascular Diseases
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DOI：
10.1007/s12272-009-1801-1
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发表时间：
2009-08-01
影响因子：
6.7
通讯作者：
Ignarro, Louis J.
中科院分区：
文献类型：
--
作者：
Napoli, Claudio;Ignarro, Louis J.
一氧化氮（NO）是心血管系统中的重要信号信使。NO参与调节功能，包括控制止血、纤维蛋白溶解、血小板和白细胞与动脉壁的相互作用、调节血管张力、血管平滑肌细胞的增殖和血压的稳态。降低的NO生物利用度和NO依赖性信号传导的异常是血管疾病的中心因素，尽管尚不清楚这是否是内皮功能障碍的原因或结果，或者两者都是致病事件。NO生物利用度的紊乱与引起内皮功能障碍有关，导致对动脉粥样硬化病变进展、高血压、高胆固醇血症、糖尿病、血栓形成和中风的易感性增加。
Nitric oxide (NO) is a pivotal signaling messenger in the cardiovascular system. NO participates in regulatory functions including control of hemostasis, fibrinolysis, platelet and leukocyte interactions with the arterial wall, regulation of vascular tone, proliferation of vascular smooth muscle cells, and homeostasis of blood pressure. Diminished NO bioavailability and abnormalities in NO-dependent signaling are among central factors of vascular disease, although it is unclear whether this is a cause of, or result of endothelial dysfunction or both pathogenic events. Disturbances in NO bioavailability have been linked to cause endothelial dysfunction, leading to increased susceptibility to atherosclerotic lesion progression, hypertension, hypercholesterolemia, diabetes mellitus, thrombosis and stroke.