Probiotic treatment increases salivary counts of lactobacilli: A double-blind, randomized, controlled study
Probiotic treatment increases salivary counts of lactobacilli: A double-blind, randomized, controlled study
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DOI：
10.1159/000076559
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发表时间：
2004-01-01
期刊：
影响因子：
3.2
通讯作者：
Gasbarrini, G
中科院分区：
文献类型：
--
作者：
Montalto, M;Vastola, M;Gasbarrini, G
背景/目的：乳酸菌被用于多种疾病的预防和治疗，但它们也被认为在龋齿的发病机制中发挥了作用。我们研究的目的是评估与安慰剂相比，口服乳酸菌是否可以改变这些细菌的唾液计数。此外，乳酸菌以液体和胶囊的形式给药，以确定直接接触口腔的作用。方法：35名健康志愿者随机分为3组，分别给予乳酸菌和/或安慰剂治疗45d，A组(n=14)口服益生菌胶囊和安慰剂，B组(n=16)口服液体益生菌和安慰剂胶囊，C组(n=5)口服液体和胶囊形式的安慰剂。以变形链球菌种群为对照。用CRT(R)细菌试剂盒半定量测定唾液中乳酸杆菌和变形链球菌的数量。结果：与安慰剂相比，口服益生菌胶囊和液体形式的益生菌显著增加唾液中乳酸杆菌的数量，分别为p=0.005和p=0.02。变形链球菌种群没有发生明显的改变。结论：唾液中乳杆菌数量的增加可能表明需要密切监测接受长期益生菌治疗的患者的牙齿健康，即使这种治疗是以避免与口腔直接接触的形式进行的。版权所有(C)2004 S.Karger AG，巴塞尔。
Background/Aims: Lactobacilli are used in the prevention and treatment of several diseases, but they are also known to play a role in the pathogenesis of dental caries. The aim of our study was to evaluate whether the oral administration of lactobacilli could change the salivary counts of these bacteria compared with placebo. Moreover, lactobacilli were administered in liquid and in capsule form to determine the role of direct contact with the oral cavity. Methods: Thirty-five healthy volunteers were randomized into three groups to receive lactobacilli and/or placebo for 45 days: group A (n = 14) received probiotics in capsules and placebo in liquid form; group B ( n = 16) took liquid probiotics and placebo in capsules, and group C ( n = 5) used placebo in both liquid and capsule form. Streptococcus mutans populations served as control. The salivary counts of lactobacilli and S. mutans were measured semi-quantitatively using the CRT(R) bacteria kit. Results: Compared with placebo, the oral administration of probiotics, both in capsules and in liquid form, significantly increases salivary counts of lactobacilli p = 0.005 and p = 0.02, respectively). S. mutans populations were not significantly modified. Conclusions: The increased salivary counts of lactobacilli may indicate the need to closely monitor the dental health of patients undergoing long-term probiotics treatment, even when this treatment is administrated in a form that avoids direct contact with the oral cavity. Copyright (C) 2004 S. Karger AG, Basel.