Electroacupuncture improves neurological deficits and enhances proliferation and differentiation of endogenous nerve stem cells in rats with focal cerebral ischemia
Electroacupuncture improves neurological deficits and enhances proliferation and differentiation of endogenous nerve stem cells in rats with focal cerebral ischemia
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DOI：
10.1179/174313209x414506
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发表时间：
2010-03-01
影响因子：
1.9
通讯作者：
Wang, Xiang-Bin
中科院分区：
文献类型：
--
作者：
Tao, Jing;Xue, Xie-Hua;Wang, Xiang-Bin
目的：本研究观察了电针对大脑中动脉闭塞（MCAO）大鼠神经功能缺损及神经干细胞（Nerve stem cells，NSCs）增殖分化的影响，探讨了电针对MCAO大鼠脑缺血损伤的治疗作用。在缺血性损伤后第4、7、14和21天，对神经功能缺损进行评分。在脑缺血后第4、7、14、21天，采用BrdU/NeuN和BrdU/GFAP免疫荧光双标记法观察电针干预对大鼠神经干细胞增殖和分化的影响。结果：脑缺血后第7、14、21天，电针干预组大鼠神经功能缺损评分与模型组比较有显著性差异（P
Objectives: This study was carried out to observe the effect of electroacupuncture (EA) on neurological deficits, proliferation and differentiation of nerve stem cells (NSCs) in adult rats with middle cerebral artery occlusion (MCAO) and to study its possible role in the treatment of cerebral ischemic injury.Methods: A rat model of MCAO was established and interfered with EA. On days 4, 7, 14 and 21 after ischemic injury, neurological deficits were scored. On days 4, 7, 14 and 21 after injury, effect of EA interference on the proliferation and differentiation of rat NSCs was observed with BrdU/NeuN and BrdU/GFAP immunofluorescence double labeling.Results: A significant difference was found in the scores of rat neurological deficits between the EA and model groups 7, 14 and 21 days after cerebral ischemic injury (p