High dietary fat promotes Syndrome X in nonobese rats
High dietary fat promotes Syndrome X in nonobese rats
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DOI：
10.1093/jn/133.7.2244
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发表时间：
2003-07-01
影响因子：
4.2
通讯作者：
Sclafani, A
中科院分区：
文献类型：
--
作者：
Axen, KV;Dikeakos, A;Sclafani, A
高脂肪、低碳水化合物饮食被广泛提倡用于减肥和改善代谢综合征X，代谢综合征X是2型糖尿病和心血管疾病的一系列危险因素。在瘦大鼠和先前通过随意食用相同的高脂肪饮食而导致肥胖的大鼠中评估了能量限制（以防止体重增加超过正常生长）高脂肪（60%的能量）、低碳水化合物（15%）饮食的影响。在肥胖大鼠中，限制摄入未能改善葡萄糖耐量受损，高胰岛素血症和高脂血症，但与继续随意摄入高脂肪饮食的大鼠相比，限制摄入降低了内脏脂肪量，肝脏脂质含量和体外胰岛素分泌过多。在瘦大鼠中，限制摄入高脂肪饮食损害了葡萄糖耐量，增加了内脏脂肪量和肝脏脂质含量。这些发现支持了以下结论：在没有减肥的情况下，高脂肪，低碳水化合物饮食不仅可能对降低心血管疾病和2型糖尿病的风险因素无效，而且可能促进先前风险较低的非肥胖个体的疾病发展。
High fat, low carbohydrate diets are popularly advocated for weight loss and improvement in metabolic Syndrome X, a constellation of risk factors for type 2 diabetes mellitus and cardiovascular disease. The effects of an energy-restricted (to prevent weight gain in excess of normal growth) high fat (60% of energy), low carbohydrate (15%) diet were assessed in both lean rats and in rats previously rendered obese through ad libitum consumption of the same high fat diet. In obese rats, restriction of intake failed to improve impaired glucose tolerance, hyperinsulinemia, and hypertriglyceridemia, although it lowered visceral fat mass, liver lipid content and in vitro insulin hypersecretion compared with rats continuing to consume the high fat diet ad libitum. In lean rats, restricted intake of the high fat diet impaired glucose tolerance and increased visceral fat mass and liver lipid content. These findings support the conclusion that, in the absence of weight loss, a high fat, low carbohydrate diet not only may be ineffective in decreasing risk factors for cardiovascular disease and type 2 diabetes but may promote the development of disease in previously lower risk, nonobese individuals.