HISTOLOGIC SPECTRUM OF BARRETTS ESOPHAGUS
HISTOLOGIC SPECTRUM OF BARRETTS ESOPHAGUS
复制标题
DOI：
10.1056/nejm197608262950904
复制
发表时间：
1976-01-01
影响因子：
158.5
通讯作者：
GOYAL, RK
中科院分区：
文献类型：
--
作者：
PAULL, A;TRIER, JS;GOYAL, RK
为了明确柱状内衬食管的组织学，我们对11例患者进行了不同水平的食管活检，并进行了压力控制。食管下括约肌上方有3种柱状上皮：萎缩性胃底型上皮，有壁细胞和主细胞；连接型上皮与心脏黏液腺；具有绒毛状表面的独特的特化柱状上皮，粘液腺体和肠型杯状细胞。当存在时，特化柱状上皮总是最近的，胃底上皮总是最远的。连接上皮介于胃底上皮和特化柱状上皮或鳞状上皮之间。4例患者在鳞状上皮中有明确的食管炎，但其存在和严重程度与远端柱状上皮的炎症或长度或类型无关。食道柱状排列的组织学研究显示了一系列上皮类型。这种异质性有助于解释先前的差异报告。
To define the histology of the columnar-lined esophagus, esophageal biopsies were obtained from various levels with manometric control from 11 patients. There were 3 types of columnar epithelia above the lower esophageal sphincter: atrophic gastric-fundic-type epithelium with parietal and chief cells; junctional-type epithelium with cardiac mucous glands; and distinctive specialized columnar epithelium with a villiform surface, mucous glands and intestinal-type goblet cells. When present, specialized columnar epithelium was always the most proximal, and gastric fundic epithelium the most distal epithelium. Junctional epithelium was interposed between gastric fundic and specialized columnar or squamous epithelium. Four patients had unequivocal esophagitis in squamous epithelium, but its presence and severity did not correlate with inflammation in or length or type of distal columnar epithelium. Histologic study of the columnar-lined esophagus demonstrated a spectrum of epithelial patterns. This heterogeneity helps to explain prior discrepant reports.