The effect of vasoactive agents on the left ventricular end-systolic pressure-volume relation in closed-chest dogs.
The effect of vasoactive agents on the left ventricular end-systolic pressure-volume relation in closed-chest dogs.
复制标题
血管活性药物对闭胸犬左心室收缩末压-容积关系的影响。
DOI：
10.1161/01.cir.74.5.1107
复制
发表时间：
1986
期刊：
影响因子：
37.8
通讯作者：
O'Rourke,RA
中科院分区：
文献类型：
--
作者：
Freeman,GL;Little,WC;O'Rourke,RA
左心室收缩末期压力-容积关系作为一种对负荷相对不敏感的心脏功能测量方法受到了广泛关注。在临床研究中，血压的药理学操作已被用于确定这种关系。由于先前的研究表明，动脉循环阻力和阻抗的急性变化会影响左心室收缩末期压力-容积关系，因此在其测定中使用血管活性药物可能会影响所获得的结果。本研究旨在确定临床使用的血管活性药物是否影响左心室收缩末期压力-容积关系。16只狗以前仪器与微压计压力传感器和三套压电晶体，以允许确定左心室压力和容量。在自主神经阻滞和镇静后对犬进行研究。在控制血压水平下，在输注血管加压药（甲氧胺，n = 6;血管紧张素II，n = 10）后，然后在输注硝普钠后，通过腔静脉闭塞产生收缩末期压力-容积关系。还使用每只犬的对照点、血管加压点和血管扩张点构建复合收缩末期压力-容积关系。血管紧张素II导致该关系发生显著变化（Vo从14.32 +/-7.3降至8.04 +/-10.4 ml，p <0.05），对斜率无显著影响。甲氧胺使关系向左移动（Vo从13.98 +/-8.74降至-0.47 +/-12.06 ml，p <0.05），也降低了斜率（5.41 +/-3.09 vs 8.28 +/-3.94 mm Hg/ml，p <0.05）。（250字处删节）
The left ventricular end-systolic pressure-volume relation has received intense interest as a relatively load-insensitive measure of cardiac performance. In clinical studies, pharmacologic manipulation of blood pressure has been used to determine this relation. Since previous studies have shown that acute changes in the resistance and impedance of the arterial circulation influence the left ventricular end-systolic pressure-volume relation, the use of vasoactive drugs in its determination may affect the results achieved. This study was undertaken to determine whether clinically used vasoactive drugs influence the left ventricular end-systolic pressure-volume relation. Sixteen dogs were previously instrumented with micromanometer pressure transducers and three sets of piezoelectric crystals to permit determination of left ventricular pressure and volume. The dogs were studied after autonomic blockade and sedation. End-systolic pressure-volume relations were generated by caval occlusion at control levels of blood pressure, after infusion of a vasopressor (methoxamine, n = 6; angiotensin II, n = 10), and then after infusion of nitroprusside. A composite end-systolic pressure-volume relation was also constructed with the use of control, vasopressor, and vasodilator points in each dog. Angiotensin II resulted in a leftward shift in the relation (Vo decreased from 14.32 +/- 7.3 to 8.04 +/- 10.4 ml, p less than .05) with no significant effect on slope. Methoxamine shifted the relation to the left (Vo decreased from 13.98 +/- 8.74 to -0.47 +/- 12.06 ml, p less than .05) and also reduced the slope (5.41 +/- 3.09 vs 8.28 +/- 3.94 mm Hg/ml, p less than .05).(ABSTRACT TRUNCATED AT 250 WORDS)