Variation in hippocampal neuron number with age and brain volume
Variation in hippocampal neuron number with age and brain volume
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DOI：
10.1093/cercor/8.8.710
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发表时间：
1998-12-01
期刊：
影响因子：
3.7
通讯作者：
Kril, JJ
中科院分区：
文献类型：
--
作者：
Harding, AJ;Halliday, GM;Kril, JJ
海马大小和神经元数量在许多情况下减少，包括颞叶癫痫和阿尔茨海默病。此外，也有人提出随着年龄的增长而减少。本研究检查了12名年龄在46至85岁之间的无神经系统疾病的受试者的整个海马结构。7个亚区（CA 1，CA 2 -3，CA 4，齿状回，下托，前下托和白色物质）的体积进行了测定，并估计在每个这些灰质亚区的神经元的数量使用光学解剖技术。海马CA 1区神经元数目与大脑体积呈显著正相关。多因素分析显示，大脑体积对CA 1区神经元数量的影响较大（69%），而年龄（2%）和性别（1%）对CA 1区神经元数量的影响较小。这项研究的结果表明，在神经系统正常的个体中，大脑大小是CA 1神经元数量的主要决定因素。
Hippocampal size and neuron number are reduced in a number of conditions, including temporal lobe epilepsy and Alzheimer's disease. Furthermore, a decrease with advancing age has also been suggested. The present study examined the entire hippocampal formation of 12 subjects aged from 46 to 85 years and free from neurological disease. The volume of seven subregions (CA1, CA2-3, CA4, dentate gyrus, subiculum, presubiculum and white matter) was determined and the number of neurons estimated in each of these grey matter subregions using the optical dissector technique. There was a significant relationship between CA1 neuron number and cerebrum volume. Multivariate analysis showed the greater contribution to the variance in CA1 neuron number was made by cerebrum volume (69%) rather than age (2%) or sex (1%). The findings of this study show that, in neurologically normal individuals, brain size is a major determinant of the number of CA1 neurons.