The Abscopal Effect of Stereotactic Radiotherapy and Immunotherapy: Fool's Gold or El Dorado?
The Abscopal Effect of Stereotactic Radiotherapy and Immunotherapy: Fool's Gold or El Dorado?
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DOI：
10.1016/j.clon.2019.04.006
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发表时间：
2019-07-01
影响因子：
3.4
通讯作者：
Hanna, G. G.
中科院分区：
文献类型：
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作者：
Xing, D.;Siva, S.;Hanna, G. G.
“远位”效应通常用于指局部照射后远处肿瘤消退。自20世纪50年代首次报道远位效应以来，单独使用放射治疗的病例非常罕见。免疫应答在远位效应中起重要作用，但其机制尚不清楚。随着最近癌症免疫疗法的成功，人们越来越关注将免疫疗法与放射疗法结合以提高远位反应率。与常规放射治疗相比，立体定向消融放射治疗（SABR）不仅可以对肿瘤提供消融剂量，而且可以诱导强烈的免疫反应。在这篇综述中，我们检查研究，结合联合收割机SABR和免疫治疗。我们回顾了SABR和免疫治疗组合的临床前原理，支持和反对远位效应的情况，以及目前的临床试验情况。(C)2019年皇家放射科医师学院。由爱思唯尔有限公司出版。保留所有权利。
An 'abscopal' effect if often used to refer to distant tumour regression after localised irradiation. Since the first report of the abscopal effect in the 1950s, well-documented cases with radiotherapy alone are very rare. It is widely accepted that the immune response plays an important role in the abscopal effect, although the mechanism is still unclear. With the recent success of cancer immunotherapy, there is growing interest in combining immunotherapy with radiotherapy to boost abscopal response rates. Compared with conventional radiotherapy, stereotactic ablative radiotherapy (SABR) not only delivers ablative dose to the tumour, but may also induce robust immune responses. In this review we examine studies that combine SABR and immunotherapy. We review the preclinical rationale for SABR and immunotherapy combinations, the case for and against abscopal effects, and the current landscape of clinical trials. (C) 2019 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.