Alcohol-related olfactory cues activate the nucleus accumbens and ventral tegmental area in high-risk drinkers: Preliminary findings
Alcohol-related olfactory cues activate the nucleus accumbens and ventral tegmental area in high-risk drinkers: Preliminary findings
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DOI：
10.1097/01.alc.0000122764.60626.af
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发表时间：
2004-04-01
影响因子：
3.2
通讯作者：
Li, TK
中科院分区：
文献类型：
--
作者：
Kareken, DA;Claus, ED;Li, TK
背景：中皮质边缘多巴胺系统与动机和奖赏有关，可能参与酒精中毒的发展。方法：我们使用功能磁共振成像研究了 10 名高危人群对酒精相关嗅觉刺激（AROS；啤酒和威士忌气味）和非酒精相关嗅觉刺激（NAROS；草和皮革气味）的血氧水平依赖性（BOLD）反应。 (HR) 饮酒者（每周平均饮酒量，19.99；SD，6.99；所有受试者都有大于或等于 2 名一级或二级酗酒亲属）和 5 名低风险（LR）社交饮酒对照者（每周平均饮酒量，2.82；SD，2.87；1 名受试者有 1 名二级酗酒亲属）。使用 SPM99 和随机效应分析，使用感兴趣区域和校正的聚类统计数据 (p < 0.05) 重点关注伏隔核 (NAc) 和腹侧被盖区 (VTA)。 结果：在 FIR 受试者中，AROS 期间 NAc 的 BOLD 信号增加比清洁空气期间更大。 AROS 期间的 BOLD 信号增加在 NAc 中也比 NAROS 诱导的信号增加更大。 VTA 中少数体素的 AROS 信号明显大于 NAROS 信号。最后，远红外饮酒者的 NAc 和 VTA 中 AROS/NAROS 差异信号更大。结论：酒精嗅觉信号可能比非酒精气味更大程度地调用多巴胺能中皮质边缘系统，并且可能是探索多巴胺系统在酒精中毒易感性中的作用的有效工具。
Background: The mesocorticolimbic dopamine system is implicated in motivation and reward and may be involved in the development of alcoholism.Methods: We used functional magnetic resonance imaging to study the blood oxygen level-dependent (BOLD) response to alcohol-related olfactory stimuli (AROS; odors of beer and whiskey) and non-alcohol-related olfactory stimuli (NAROS; odors of grass and leather) in 10 high-risk (HR) drinkers (average drinks per week, 19.99; SD, 6.99; all with greater than or equal to2 first- or second-degree alcoholic relatives) and 5 low-risk (LR) social drinking controls (drinks per week, 2.82; SD, 2.87; 1 subject had 1 second-degree alcoholic relative). Data were analyzed with SPM99 and random effects analysis by using regions of interest and corrected cluster statistics (p < 0.05) to focus on the nucleus accumbens (NAc) and ventral tegmental area (VTA).Results: In FIR subjects, there was a greater BOLD signal increase in the NAc during AROS than during clean air. BOLD signal increases during AROS were also greater in the NAc than the signal increases induced by NAROS. The AROS signal was significantly greater than the NAROS signal in a small number of voxels in the VTA. Finally, the AROS/NAROS difference signal was larger in FIR drinkers in both the NAc and VTA.Conclusions: Alcoholic olfactory cues may invoke the dopaminergic mesocorticolimbic system to a greater degree than nonalcoholic odors and could be effective tools in exploring the role of the dopamine system in susceptibility to alcoholism.