The role of ventral and orbital prefrontal cortex in conditional visuomotor learning and strategy use in rhesus monkeys (Macaca mulatta)
The role of ventral and orbital prefrontal cortex in conditional visuomotor learning and strategy use in rhesus monkeys (Macaca mulatta)
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DOI：
10.1037//0735-7044.115.5.971
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发表时间：
2001-10-01
影响因子：
1.9
通讯作者：
Murray, EA
中科院分区：
文献类型：
--
作者：
Bussey, TJ;Wise, SP;Murray, EA
四只恒河猴（Macaca mulatta）被训练在50次或更少的试验中学习新的视觉联想。在双侧眶前额叶皮层和腹前额叶皮层消融后，猴子失去了在一个会话中学习这些关联的能力，尽管他们可以在每天几次的会话中学习它们。因此，相对缓慢的跨会话视觉学习既不依赖于腹前额叶皮层，也不依赖于眶前额叶皮层。但快速的会话内团队合作可以。消融还消除了至少2种反应策略，重复停留和损失转移。这可能是快速学习能力不足的部分原因。这种缺陷不太可能是由于视觉辨别能力或工作记忆的失败造成的：猴子可以在一段时间内辨别类似的刺激材料。而减少工作记忆负荷并不能改善会话内学习。
Four rhesus monkeys (Macaca mulatta) were trained to learn novel sets of visuomotor associations in 50 trials or less. within single test sessions. After bilateral ablation of the orbital and ventral prefrontal cortex, the monkeys lost the ability to learn these associations within a session, although they could learn them when given several daily sessions, Thus, relatively slow, across-session visuomotor learning depends on neither the ventral nor orbital prefrontal cortex. but rapid, within-session teaming does. The ablations also eliminated at least 2 response strategies, repeat-stay and lose-shift. which might account, in part, for the deficit in rapid learning. The deficit is unlikely to result from a failure of visual discriminative ability or working memory: The monkeys could discriminate similar stimulus material within a session. and reducing the working memory load did not improve within-session learning.