A Study of Brain Metabolism in Fibromyalgia by Positron Emission Tomography
A Study of Brain Metabolism in Fibromyalgia by Positron Emission Tomography
复制标题
正电子发射断层扫描研究纤维肌痛的脑代谢
DOI：
10.1016/j.pnpbp.2017.01.012
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Nishioka K
中科院分区：
文献类型：
--
作者：
Usui C;Soma T;Hatta K;Aratani S;Fujita H;Nishioka K;Machida Y;Kuroiwa Y;Nakajima T;Nishioka K
PurposeThe的目的，本研究的目的是确定脑区与治疗初治纤维肌痛（FM）的患者代谢改变，我们使用[18 F]氟-d-葡萄糖正电子发射断层扫描检查共18个治疗初治FM患者和18个年龄和性别匹配的健康对照组没有痛苦。使用统计参数mapping.ResultsNo显着体素（峰值）水平的结果进行了体素的体素组分析，在这项研究中检测到，但是，一些地区被检测到显着的大小集群。FM患者和对照组之间的脑代谢无显著差异。然而，右丘脑和左豆状核是高代谢区FM患者与健康对照组相比，预后差。与健康对照组相比，FM患者的左丘脑和左豆状核是低代谢区，预后良好。与FM患者预后良好，FM患者预后不良表现出显着的高代谢在左侧丘脑，双侧豆状核，和右侧海马旁gyrus.ConclusionThe目前的研究结果表明，在丘脑，豆状核，海马旁回和FM患者的预后代谢之间的关联。需要更多患者的进一步研究来证实这种关联。
PurposeThe aim of the present study was to determine the brain regions with altered metabolism in patients with treatment-naïve fibromyalgia (FM).MethodsWe used [18F] fluoro-d-glucose positron emission tomography to examine a total of 18 treatment-naïve FM patients and 18 age- and sex-matched healthy controls not suffering from pain. A voxel-by-voxel group analysis was performed using statistical parametric mapping.ResultsNo significant voxel (peak)-level results were detected in this study; however, some regions were detected as significant-size clusters. There were no significant differences in brain metabolism between FM patients and controls. However, the right thalamus and left lentiform nucleus were hypermetabolic areas in FM patients with poor prognosis compared to the healthy controls. In contrast, the left insula and left lentiform nucleus were hypometabolic areas in FM patients with good prognosis compared to the healthy controls. Compared to FM patients with good prognosis, FM patients with poor prognosis showed significant hypermetabolism in the left thalamus, bilateral lentiform nucleus, and right parahippocampal gyrus.ConclusionThe present findings suggest an association between the metabolism in the thalamus, lentiform nucleus, and parahippocampal gyrus and prognosis in FM patients. Further study with a larger number of patients is required to confirm this association.