In utero ethanol exposure decreases rapid eye movement sleep in female Sprague-Dawley rat offspring
In utero ethanol exposure decreases rapid eye movement sleep in female Sprague-Dawley rat offspring
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DOI：
10.1016/s0304-3940(00)01261-1
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发表时间：
2000-07-28
影响因子：
2.5
通讯作者：
Smith, C
中科院分区：
文献类型：
--
作者：
Sylvester, L;Kapron, CM;Smith, C
有大量证据表明，在胎儿期身体生长的脆弱时期，乙醇暴露会导致后代出现许多形态异常和认知缺陷。受影响的个体表现出的特征之一是异常的睡眠模式，特别是异常的快速眼动（REM）睡眠。为了更好地了解产前乙醇暴露如何特别影响后代的睡眠模式，使用Sprague-Dawley大鼠研究了胎儿酒精综合征的动物模型。我们的研究表明，与雄性和雌性盐水对照组相比，雌性大鼠在子宫内暴露于乙醇中的REM睡眠时间减少，但雄性大鼠没有减少。同样，生理盐水对照组雌性大鼠的REM睡眠百分比几乎是暴露于乙醇的雌性大鼠的两倍（11.9 vs. 6.9%）。相比之下，乙醇处理组和生理盐水对照组雄性动物的% REM测量值无差异（11.5 vs. 10.4%），与生理盐水对照组雌性动物也无差异。在慢波睡眠或觉醒时间方面，未观察到雄性和雌性动物或给药组之间存在差异。(C)2000年由爱思唯尔科学爱尔兰有限公司出版
There is substantial evidence to suggest that ethanol exposure during vulnerable periods of prenatal somatic growth results in a number of morphological abnormalities and cognitive deficits in offspring. Amongst the characteristics exhibited by affected individuals are abnormal sleeping patterns, particularly abnormal rapid eye movement (REM) sleep. To better understand how prenatal ethanol exposure specifically affects sleeping patterns in offspring, an animal model of fetal alcohol syndrome was investigated using the Sprague-Dawley rat. Our study demonstrated that the amount of time spent in REM sleep was reduced in female, but not male rats, which were exposed to ethanol in utero as compared to male and female saline controls. Similarly, % REM sleep for female saline control rats was almost twice that of females exposed to ethanol (11.9 vs. 6.9%). By contrast, ethanol treated and control saline males did not differ on the % REM measure (11.5 vs. 10.4%), nor did they differ from the female saline controls. No differences were observed between males and females or treatment groups in terms of time spent in either slow wave sleep or wakefulness. (C) 2000 Published by Elsevier Science Ireland Ltd.