Nerve growth cone motility.
Nerve growth cone motility.
复制标题
神经生长锥运动。
DOI：
10.1016/s0955-0674(05)80035-3
复制
发表时间：
1990
影响因子：
7.5
通讯作者：
Letourneau,P
中科院分区：
文献类型：
--
作者：
Lankford,K;Cypher,C;Letourneau,P
Although many issues remain unresolved, the past year has witnessed a number of advances in our understanding of the inter-relationships between extracellular influences, cell phenotype, growth associated proteins, second messengers, and cytoskeletal components in the control of neurite outgrowth and growth cone behavior. Some of the early events associated with process initiation have been tentatively identified, and more is known about the assembly and stabilization of the microtubular framework of growing neurites. The mechanical forces involved in neurite extension have begun to be quantified, and interactions between the actin and microtubule systems are being further characterized. The current data more strongly support a functional role for GAP-43 in control of motility. The data also tend to support a central role for cytoplasmic calcium in mediating the actions of many growth-regulating influences, and strongly implicate changes in actin filament stability as mediating the behavioral effects of calcium (Fig. 1).
