Aberrant functional connectivity differentiates retrosplenial cortex from posterior cingulate cortex in prodromal Alzheimer's disease
Aberrant functional connectivity differentiates retrosplenial cortex from posterior cingulate cortex in prodromal Alzheimer's disease
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DOI：
10.1016/j.neurobiolaging.2016.04.010
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发表时间：
2016-08-01
影响因子：
4.2
通讯作者：
Fink, Gereon R.
中科院分区：
文献类型：
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作者：
Dillen, Kim N. H.;Jacobs, Heidi I. L.;Fink, Gereon R.
后扣带皮层 (PCC) 是默认模式网络的关键枢纽，默认模式网络是一种涉及情景记忆的静息态网络，显示阿尔茨海默病 (AD) 中的功能连接 (FC) 变化。然而，PCC 是一个细胞结构异质区域。具体来说，压后皮质 (RSC) 通常包含在 PCC 之下，在功能和微观解剖学上与 PCC 不同。为了分别研究 RSC 和 PCC 的 FC 模式，我们对健康老龄参与者、主观认知障碍患者和前驱 AD 患者使用静息态功能磁共振成像。与其他两组相比，我们发现主观认知障碍中从 RSC 到额叶皮层的 FC 较高，但在前驱 AD 中从 RSC 到枕叶皮层的 FC 较高。相反，在 AD 前驱期，从 PCC 到舌回的 FC 较高。此外，数据表明，与认知正常个体相比，RSC 和 PCC 的特征是不同的 FC 模式，该模式以中枢特异性相互作用为代表，与认知正常的个体相比，前驱 AD 中的记忆和注意力评分得分，可能反映了 RSC 的补偿机制和 PCC 的神经退行性过程。因此，数据证实并扩展了先前的研究，表明 RSC 在功能上与 PCC 不同。 (C) 2016 Elsevier Inc. 保留所有权利。
The posterior cingulate cortex (PCC) is a key hub of the default mode network, a resting-state network involved in episodic memory, showing functional connectivity (FC) changes in Alzheimer's disease (AD). However, PCC is a cytoarchitectonically heterogeneous region. Specifically, the retrosplenial cortex (RSC), often subsumed under the PCC, is an area functionally and microanatomically distinct from PCC. To investigate FC patterns of RSC and PCC separately, we used resting-state functional magnetic resonance imaging in healthy aging participants, patients with subjective cognitive impairment, and prodromal AD. Compared to the other 2 groups, we found higher FC from RSC to frontal cortex in subjective cognitive impairment but higher FC to occipital cortex in prodromal AD. Conversely, FC from PCC to the lingual gyrus was higher in prodromal AD. Furthermore, data indicate that RSC and PCC are characterized by differential FC patterns represented by hub-specific interactions with memory and attentions scores in prodromal AD compared to cognitively normal individuals, possibly reflecting compensatory mechanisms for RSC and neurodegenerative processes for PCC. Data thus confirm and extend previous studies suggesting that the RSC is functionally distinct from PCC. (C) 2016 Elsevier Inc. All rights reserved.