Recent advances in nickel-catalyzed reductive hydroalkylation and hydroarylation of electronically unbiased alkenes
Recent advances in nickel-catalyzed reductive hydroalkylation and hydroarylation of electronically unbiased alkenes
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DOI：
10.1007/s11426-020-9838-x
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发表时间：
2020-09
期刊：
影响因子：
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通讯作者：
Xiao-Xu Wang;Xi Lu;Yan Li;Jia-Wang Wang-Jia-Wang-Wang-120465670;Yao Fu
中科院分区：
文献类型：
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作者：
Xiao-Xu Wang;Xi Lu;Yan Li;Jia-Wang Wang-Jia-Wang-Wang-120465670;Yao Fu
利用简单易得的原料，通过过渡金属催化构建C(sp3)-C键，快速高效地获得具有复杂分子结构的化合物具有重要意义。作为传统的C(sp3)-C偶联试剂，烷基金属试剂往往存在空气和湿度敏感性以及储存困难等局限性。镍催化还原烯烃加氢反应利用烯烃替代有机金属试剂，减少了合成步骤，提高了官能团相容性，扩大了底物范围。本文综述了近年来在电子无偏烯烃加氢烷基化和加氢芳基化方面的重要进展，并阐述了其关键机理和应用。
The use of simple and easily available feedstock to quickly and efficiently obtain compounds with complex molecular structures through the transition-metal-catalyzed construction of C(sp3)-C bonds has important significance. As traditional C(sp3)-C coupling reagents, alkylmetallic reagents often have limitations such as air and moisture sensitivity and difficulties in storage. Nickel-catalyzed reductive olefin hydrocarbonation reactions use alkenes to replace organometallic reagents, reduce the synthesis steps, improve the functional group compatibility, and expand the substrate scope This minireview discusses important progress in the hydroalkylation and hydroarylation of electronically unbiased alkenes in recent years and describes the key mechanism and applications.