Effects of race and ethnicity on the incidence of venous thromboembolism
Effects of race and ethnicity on the incidence of venous thromboembolism
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DOI：
10.1016/s0049-3848(09)70136-7
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发表时间：
2009-01-01
影响因子：
7.5
通讯作者：
Keenan, Craig R.
中科院分区：
文献类型：
--
作者：
White, Richard H.;Keenan, Craig R.
尽管有强有力的证据表明，静脉血栓栓塞（VTE）的患病率在不同种族/种族群体之间存在显著差异，但这些差异的遗传、生理和/或临床基础在很大程度上仍不明确。非裔美国人患者的静脉血栓栓塞事件发生率明显更高，特别是在暴露于手术、医疗疾病、创伤等激发风险因素之后。此外，与高加索人和其他种族群体相比，非裔美国人更有可能被诊断出患有肺栓塞（PE）而不是深静脉血栓形成（DVT）。在另一个极端，亚洲人/太平洋岛民的VTE患病率低70%，这对于特发性VTE和诱发性或“继发性”VTE都是如此。与白人相比，西班牙裔人的VTE患病率明显较低，但高于亚洲人/太平洋岛民。复发性VTE的发生率因性别、血栓栓塞事件类型和种族而异。需要进一步研究，以确定种族/族裔群体之间的根本差异，解释观察到的VTE患病率差异。人种/种族应被视为疑似VTE患者或存在发生VTE风险的患者风险分层的重要因素。(C)2009爱思唯尔有限公司版权所有。
Although there is strong evidence that the prevalence of venous thromboembolism (VTE) varies significantly among different ethnic/racial groups, the genetic, physiologic and/or clinical basis for these differences remain largely undefined. African-American patients have a significantly higher rate of incident VTE, particularly following exposure to a provoking risk factor such as surgery, medical illness, trauma, etc. In addition, African-Americans are more likely to be diagnosed with pulmonary embolism (PE) than deep-vein thrombosis (DVT) compared to Caucasian and other racial groups. On the other extreme, Asians/Pacific Islanders have a 70% lower prevalence of VTE and this is true for both idiopathic VTE and provoked, or 'secondary', VTE. Hispanics have a significantly lower prevalence of VTE compared to Caucasians, but higher than Asians/Pacific Islanders. The incidence of recurrent VTE varies depending on gender, type of thromboembolic event and race. Further research is needed in order to determine the fundamental differences between racial/ethnic groups that explain the observed differences in the prevalence of VTE. Race/ethnicity should be considered an important factor in the risk-stratification of patients with suspected VTE or patients at some risk for developing VTE. (C) 2009 Elsevier Ltd. All rights reserved.