First passage and cooperativity of queuing kinetics
First passage and cooperativity of queuing kinetics
复制标题
DOI：
10.1103/physrevlett.95.170603
复制
发表时间：
2005-10-21
影响因子：
8.6
通讯作者：
Chou, T
中科院分区：
文献类型：
--
作者：
D'Orsogna, MR;Chou, T
我们模拟配体-受体系统的动力学，其中多个配体可以随机地或以特定的顺序与受体结合和解结合。平衡占领和第一次发生的完全填充的受体的测定和比较。在平衡状态下，顺序结合配体的受体比随机结合的受体更容易饱和。然而，令人惊讶的是，对于低协同性，随机过程首先达到完全占用速度比顺序。这是真的，除了在临界结合能附近，当结合位点的数量N >= 8时，出现“动力学陷阱”并且随机过程显著减慢。这些结果表明，一个广泛的类的动力学现象，包括化学结合，成核，和装配线策略的协同性和顺序性之间的微妙的相互作用。
We model the kinetics of ligand-receptor systems, where multiple ligands may bind and unbind to the receptor, either randomly or in a specific order. Equilibrium occupation and first occurrence of complete filling of the receptor are determined and compared. At equilibrium, receptors that bind ligands sequentially are more likely to be saturated than those that bind in random order. Surprisingly however, for low cooperativity, the random process first reaches full occupancy faster than the sequential one. This is true except near a critical binding energy where a "kinetic trap'' arises and the random process dramatically slows down when the number of binding sites N >= 8. These results demonstrate the subtle interplay between cooperativity and sequentiality for a wide class of kinetic phenomena, including chemical binding, nucleation, and assembly line strategies.