Iron supplementation does not worsen respiratory health or alter the sputum microbiome in cystic fibrosis
Iron supplementation does not worsen respiratory health or alter the sputum microbiome in cystic fibrosis
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DOI：
10.1016/j.jcf.2013.11.004
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发表时间：
2014-05-01
影响因子：
5.2
通讯作者：
O'Toole, George A.
中科院分区：
文献类型：
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作者：
Gifford, Alex H.;Alexandru, Diana M.;O'Toole, George A.
背景：补充铁剂治疗低铁性贫血可能会增强囊性纤维化 (CF) 肺中的细菌生长，但缺乏检验这一假设的临床试验。方法：22 名患有 CF 和低铁性贫血的成人参加了一项随机、双盲、安慰剂对照、交叉试验，硫酸亚铁每天 325 mg，为期 6 周。铁相关血液学参数、人体测量数据、痰铁、阿克伦肺加重评分（PES）；并对痰微生物组进行了连续评估。使用固定效应模型来描述硫酸亚铁如何影响这些变量。结果：硫酸亚铁使血清铁增加 22.3%，转铁蛋白饱和度 (TSAT) 较基线增加 26.8%（p
Background: Iron supplementation for hypoferremic anemia could potentiate bacterial growth in the cystic fibrosis (CF) lung, but clinical trials testing this hypothesis are lacking.Methods: Twenty-two adults with CF and hypoferrmic anemia participated in a randomized, double-blind, placebo-controlled, crossover trial of ferrous sulfate 325 mg daily for 6 weeks. Iron-related hematologic parameters, anthropometric data, sputum iron, Akron Pulmonary Exacerbation Score (PES); and the sputum microbiome were serially assessed. Fixed-effect models were used to describe how ferrous sulfate affected these variables.Results: Ferrous sulfate increased serum iron by 22.3% and transferrin saturation (TSAT) by 26.8% from baseline (p