Neutrophils in the Tumor Microenvironment
Neutrophils in the Tumor Microenvironment
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DOI：
10.1007/978-3-030-35723-8_1
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Singh, Rakesh K.
中科院分区：
文献类型：
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作者：
Wu, Lingyun;Saxena, Sugandha;Singh, Rakesh K.
中性粒细胞是炎症、感染和损伤的第一反应者。中性粒细胞作为免疫系统中含量最丰富的白细胞之一，通过促进血管生成、免疫抑制和肿瘤转移等多种机制在肿瘤进展中发挥重要作用。最近的研究表明，中性粒细胞与淋巴细胞的比率升高，表明中性粒细胞是癌症疾病状态的潜在治疗靶点和生物标志物。本章将讨论肿瘤微环境中性粒细胞的表型和功能变化，中性粒细胞促进肿瘤转移的潜在机制(S)，以及中性粒细胞作为预后/诊断标志物和治疗靶点的临床潜力。
Neutrophils are the first responders to inflammation, infection, and injury. As one of the most abundant leukocytes in the immune system, neutrophils play an essential role in cancer progression, through multiple mechanisms, including promoting angiogenesis, immunosuppression, and cancer metastasis. Recent studies demonstrating elevated neutrophil to lymphocyte ratios suggest neutrophil as a potential therapeutic target and biomarker for disease status in cancer. This chapter will discuss the phenotypic and functional changes in the neutrophil in the tumor microenvironment, the underlying mechanism(s) of neutrophil facilitated cancer metastasis, and clinical potential of neutrophils as a prognostic/diagnostic marker and therapeutic target.