Parkinson's Disease Dementia and Dementia with Lewy Bodies Have Similar Neuropsychological Profiles
Parkinson's Disease Dementia and Dementia with Lewy Bodies Have Similar Neuropsychological Profiles
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DOI：
10.3389/fneur.2018.00123
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发表时间：
2018-03-12
影响因子：
3.4
通讯作者：
Narayanan, Nandakumar S.
中科院分区：
文献类型：
--
作者：
Aldridge, Georgina M.;Birnschein, Allison;Narayanan, Nandakumar S.
帕金森病痴呆（PDD）和路易体痴呆（DLB）是世界范围内痴呆的常见原因。尽管基于运动症状的相对时间发病与痴呆的诊断被认为是不同的实体，但这些疾病是否真的具有不同的认知特征尚不清楚。我们假设严格按照时间标准分为PDD和DLB的患者会有不同的神经心理特征。我们通过爱荷华大学对PDD和DLB患者的神经心理测试来调查这个问题。我们对到爱荷华大学痴呆和运动障碍诊所就诊的临床诊断为PDD或DLB的患者进行了回顾性图表分析和神经心理测试。47例经主治神经病学家诊断为PDD或DLB的患者被纳入研究。比较各组之间的神经心理表现，并将其作为运动诊断与痴呆诊断的相对时间的函数。我们发现PDD和DLB患者在执行功能、视觉空间处理和语言学习方面都有严重的缺陷。然而，我们发现各组之间的神经心理表现没有显著差异，神经心理表现不能可靠地解释运动诊断与痴呆诊断的相对时间。我们的数据支持DLB和PDD属于神经心理学谱系的观点。
Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are common causes of dementia worldwide. Although considered separate entities based on the relative temporal onset of motor symptoms vs. diagnosis of dementia, it is unknown if these diseases truly have distinct cognitive profiles. We hypothesized that patients divided into PDD and DLB categories strictly by temporal criteria would have different neuropsychological profiles. We investigated this question via neuropsychological testing of PDD and DLB patients at the University of Iowa. We performed retrospective chart analysis and review of neuropsychological testing of clinically diagnosed patients with PDD or DLB, who had presented to University of Iowa's dementia and movement disorder clinics. Forty-seven patients diagnosed by the treating neurologist as PDD or DLB were included. Neuropsychological performance was compared between groups, and as a function of the relative timing of the motor diagnosis vs. diagnosis of dementia. We found that both PDD and DLB patients showed severe deficits in executive function, visual-spatial processing, and verbal learning. However, we found no significant differences in neuropsychological performance between groups, and neuropsychological performance could not reliably account for the relative timing of motor diagnosis vs. diagnosis of dementia. Our data support the idea that DLB and PDD are on a neuropsychological spectrum.