Lifestyle modifications: coordinating the tRNA epitranscriptome with codon bias to adapt translation during stress responses
Lifestyle modifications: coordinating the tRNA epitranscriptome with codon bias to adapt translation during stress responses
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DOI：
10.1186/s13059-018-1611-1
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发表时间：
2018-12-27
期刊：
影响因子：
12.3
通讯作者：
Begley, Thomas J.
中科院分区：
文献类型：
--
作者：
Chan, Cheryl;Phuong Pham;Begley, Thomas J.
细胞通过改变多个水平的基因表达来适应压力。在这里，我们提出了一种在翻译水平上调节应激依赖性基因表达的新机制，在应激反应基因家族中，tRNA 表观转录组和偏向密码子使用之间具有协调的相互作用。在此模型中，同义密码子使用中包含的辅助遗传信息能够通过 tRNA 表观转录组的动态变化来调节密码子偏倚和功能相关的转录本。该模型部分解释了同步应激依赖性表观转录组标记与翻译调控转录本家族中显着的多密码子使用偏差之间的关联。该模型还预测病毒感染期间的翻译适应。
Cells adapt to stress by altering gene expression at multiple levels. Here, we propose a new mechanism regulating stress-dependent gene expression at the level of translation, with coordinated interplay between the tRNA epitranscriptome and biased codon usage in families of stress-response genes. In this model, auxiliary genetic information contained in synonymous codon usage enables regulation of codon-biased and functionally related transcripts by dynamic changes in the tRNA epitranscriptome. This model partly explains the association between synchronous stress-dependent epitranscriptomic marks and significant multi-codon usage skewing in families of translationally regulated transcripts. The model also predicts translational adaptation during viral infections.