Looking Beyond Structure: Membrane Phospholipids of Skeletal Muscle Mitochondria.
Looking Beyond Structure: Membrane Phospholipids of Skeletal Muscle Mitochondria.
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DOI：
10.1016/j.tem.2016.05.007
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发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
Funai K
中科院分区：
文献类型：
--
作者：
Heden TD;Neufer PD;Funai K
骨骼肌线粒体是高度动态的，能够极大地扩展，以满足细胞的能量需求。线粒体质量的这种增殖需要酶和结构磷脂的同步供应。虽然线粒体酶的转录调控已被广泛研究，但关于线粒体膜脂质如何在骨骼肌中产生的信息有限。在这里，我们描述了构成线粒体膜的磷脂的每一类是如何合成和/或进口的，并总结了遗传证据表明，膜磷脂组合物代表了骨骼肌线粒体呼吸功能的重要调节剂。我们还讨论了骨骼肌线粒体磷脂如何介导饮食和运动对氧化代谢的影响。
Skeletal muscle mitochondria are highly dynamic and capable of tremendous expansion to meet cellular energetic demands. Such proliferation in mitochondrial mass requires a synchronized supply of enzymes and structural phospholipids. While transcriptional regulation of mitochondrial enzymes has been extensively studied, there is limited information on how mitochondrial membrane lipids are generated in skeletal muscle. Herein we describe how each class of phospholipids that constitute mitochondrial membranes are synthesized and/or imported, and summarize genetic evidence indicating that membrane phospholipid composition represents a significant modulator of skeletal muscle mitochondrial respiratory function. We also discuss how skeletal muscle mitochondrial phospholipids may mediate the effect of diet and exercise on oxidative metabolism.