More to muscle than MyoD
More to muscle than MyoD
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比 MyoD 更注重肌肉
DOI：
10.1038/344378a0
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发表时间：
1990
期刊：
影响因子：
64.8
通讯作者：
M. Robertson
中科院分区：
文献类型：
--
作者：
M. Robertson
三年前，Harold Weintraub 及其同事发表了一项引人注目的声明：将单个基因 MyoD 引入小鼠成纤维细胞可以诱导成纤维细胞分化为肌肉。他们得出的结论是，MyoD 编码了骨骼肌分化的主调节器，并刺激了许多后续研究，结果原始图像的惊人简单性在很大程度上丢失了。因此，在本期第 454 页，Schafer 等人。 2 报道称，将 MyoD 引入肝细胞不足以诱导肌肉特异性基因的表达，但如果转染的肝细胞随后与成纤维细胞融合，则可以激活该基因。这意味着 MyoD 的主调节活性实际上是其他蛋白质的奴隶，这些蛋白质在肝细胞中抑制它，但在成纤维细胞中协助它。这与目前已知的 MyoD 结构和作用一致。
THREE years ago, Harold Weintraub and colleagues published1 the arresting claim that the introduction of a single gene, MyoD, into mouse fibroblasts could induce the fibroblasts to differentiate as muscle. They concluded that MyoD encodes a master-regulator for skeletal muscle differentiation and stimulated much subsequent research as a result of which the striking simplicity of the original picture has been largely lost. Thus on page 454 of this issue, Schafer et at. 2 report that the introduction of MyoD into liver cells is not sufficient to induce the expression of muscle-specific genes, which can however be activated if the transfected liver cell is then fused with a fibroblast. The implication is that the master-regulatory activity of MyoD is in fact slave to other proteins which suppress it in liver cells but assist it in fibroblasts. This is consistent with what is now known about the structure and action of MyoD.