Anti-inflammatory mechanism of ginseng saponins in activated microglia
Anti-inflammatory mechanism of ginseng saponins in activated microglia
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DOI：
10.1016/j.jneuroim.2009.01.020
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发表时间：
2009-04-30
影响因子：
3.3
通讯作者：
Kim, Hee-Sun
中科院分区：
文献类型：
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作者：
Park, Jin-Sun;Park, Eun-Mi;Kim, Hee-Sun
在本研究中，我们研究了人参提取物（KRG）和总皂苷（GTS）对小胶质细胞激活的影响。KRG和GTS抑制lps诱导的小胶质细胞iNOS、MMP-9和促炎因子的表达。人参对LPS致炎小鼠脑内小胶质细胞的激活也有抑制作用。此外，KRG和GTS显著抑制炎症上游信号分子NF-kappa B和MAP激酶活性。在所检测的人参皂苷中，Rh2、Rh3和化合物K显著抑制lps诱导的iNOS和细胞因子的表达。因此，人参皂苷抑制小胶质细胞的激活可能是一种潜在的治疗神经退行性疾病的方法。(C) 2009 Elsevier B.V.版权所有
In the present study, we investigated the effect of ginseng extract (KRG) and total saponins (GTS) on microglial activation. KRG and GTS inhibited LPS-induced expression of iNOS, MMP-9 and proinflammatory cytokines in microglial cells. Suppression of microglial activation by ginseng was also observed in the mouse brain inflamed by LPS. Furthermore, KRG and GTS significantly suppressed NF-kappa B and MAP kinase activities, which are upstream signaling molecules in inflammation. Among the individual ginsenosides tested, Rh2, Rh3 and compound K significantly inhibited LPS-induced iNOS and cytokine expressions. Therefore, the inhibition of microglial activation by ginseng saponins may a good potential therapeutic modality for neurodegenerative diseases. (C) 2009 Elsevier B.V. All rights reserved.