CHRONIC INFECTIONS AND INFLAMMATORY PROCESSES AS CANCER RISK-FACTORS - POSSIBLE ROLE OF NITRIC-OXIDE IN CARCINOGENESIS
CHRONIC INFECTIONS AND INFLAMMATORY PROCESSES AS CANCER RISK-FACTORS - POSSIBLE ROLE OF NITRIC-OXIDE IN CARCINOGENESIS
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DOI：
10.1016/0027-5107(94)90245-3
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发表时间：
1994-03-01
期刊：
影响因子：
--
通讯作者：
BARTSCH, H
中科院分区：
文献类型：
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作者：
OHSHIMA, H;BARTSCH, H
细菌、寄生虫或病毒感染以及胃炎、肝炎和结肠炎等组织炎症是各种部位人类癌症的公认风险因素。本文结合作者对肝吸虫感染与胆管癌发生发展的研究，讨论了感染和炎症组织中产生的一氧化氮（NO）等氧自由基通过不同的机制参与胆管癌的发生过程。类似的机制可能适用于其他可疑和已知的致癌因素，包括幽门螺杆菌感染（胃癌）或石棉暴露（肺间皮瘤）。对NO和其他活性氧产生的组织和DNA损伤类型的研究，为慢性炎症过程可能引发或增强人类致癌作用的分子机制提供了新的线索。
Infection by bacteria, parasites or viruses and tissue inflammation such as gastritis, hepatitis and colitis are recognized risk factors for human cancers at various sites. Nitric oxide (NO) and other oxygen radicals produced in infected and inflamed tissues could contribute to the process of carcinogenesis by different mechanisms, which are discussed on the basis of authors' studies on liver fluke infection and cholangiocarcinoma development. A similar mechanism could apply to other suspected and known cancer-causing agents including Helicobacter pylori infection (stomach cancer) or asbestos exposure (lung mesothelioma). Studies on the type of tissue and DNA damage produced by NO and by other reactive oxygen species are shedding new light on the molecular mechanisms by which chronic inflammatory processes may initiate or enhance carcinogenesis in humans.