Transcriptional Regulation of the Fetal Cardiac Gene Program
Transcriptional Regulation of the Fetal Cardiac Gene Program
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DOI：
10.1254/jphs.12r04cp
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发表时间：
2012-07-01
影响因子：
3.5
通讯作者：
Nakao, Kazuwa
中科院分区：
文献类型：
--
作者：
Kuwahara, Koichiro;Nishikimi, Toshio;Nakao, Kazuwa
在成人中，胎儿心脏基因程序的重新激活是心肌肥大和心力衰竭的可靠标志。正常情况下，这组基因在发育过程中在胎儿脑室表达，但在出生后保持沉默。然而，随着各种心血管疾病的发生，它们在心室肌中重新表达，并在心脏重塑的病理过程中发挥重要作用。因此，对控制胎儿心脏基因表达的分子机制的分析可能导致发现涉及心脏分化和心脏疾病的转录调控和信号通路。在这篇综述中，我们将总结目前已知的关于胎儿心脏基因程序转录调控的情况。
Reactivation of the fetal cardiac gene program in adults is a reliable marker of cardiac hypertrophy and heart failure. Normally, genes within this group are expressed in the fetal ventricles during development, but are silent after birth. However, their expression is re-induced in the ventricular myocardium in response to various cardiovascular diseases, and potentially plays an important role in the pathological process of cardiac remodeling. Thus, analysis of the molecular mechanisms that govern the expression of fetal cardiac genes could lead to the discovery of transcriptional regulators and signaling pathways involved in both cardiac differentiation and cardiac disease. In this review we will summarize what is currently known about the transcriptional regulation of the fetal cardiac gene program.