Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells.
Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells.
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DOI：
10.3389/fphar.2022.897791
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发表时间：
2022
影响因子：
5.6
通讯作者：
Hu, Zhenbo
中科院分区：
文献类型：
--
作者：
Lai, Xingrong;Sun, Yanhua;Zhang, Xuedi;Wang, Dan;Wang, Jialing;Wang, Haihua;Zhao, Yao;Liu, Xinling;Xu, Xin;Song, Haoran;Ping, Wenjia;Sun, Yanli;Hu, Zhenbo
急性髓系白血病（Acute myeloid leukemia， AML）是死亡率较高的恶性血液病之一。找到一种更有效、更容易获得的治疗方法至关重要。本研究旨在鉴定天然小分子化合物檀香醇对AML细胞系（包括THP-1、U-937和SKM-1）的抗白血病作用，并探索其潜在的生物学途径和机制。结果表明，厚朴酚降低靶向AML细胞的活力，诱导其细胞周期阻滞在G0/G1期，抑制其集落形成能力。在THP-1和U-937细胞中，本木酚还通过显著上调细胞内脂质过氧化和HMOX1水平，触发非典型铁凋亡途径。随后的研究证实HMOX1是檀香醇诱导的铁凋亡的关键靶点。这些结果表明，在AML细胞系中，本木酚是一种有效的抗白血病药物，可能是AML中潜在的铁下垂激活剂。
Acute myeloid leukemia (AML) is one of the malignant hematological cancers with high mortality. Finding a more effective and readily available treatment is of the utmost importance. Here, we aimed to identify the anti-leukemia effect of a natural small molecule compound honokiol on a panel of AML cell lines, including THP-1, U-937, and SKM-1, and explored honokiol’s potential biological pathways and mechanisms. The results showed that honokiol decreased the viability of the targeted AML cells, induced their cell cycle arrest at G0/G1 phase, and inhibited their colony-formation capacity. Honokiol also triggers a noncanonical ferroptosis pathway in THP-1 and U-937 cells by upregulating the level of intracellular lipid peroxide and HMOX1 significantly. Subsequent studies verified that HMOX1 was a critical target in honokiol-induced ferroptosis. These results reveal that honokiol is an effective anti-leukemia agent in AML cell lines and may be a potential ferroptosis activator in AML.
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影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
DOI：
10.3390/v7092852
发表时间：
2015-09-10
期刊：
Viruses
影响因子：
--
作者：
Fang CY;Chen SJ;Wu HN;Ping YH;Lin CY;Shiuan D;Chen CL;Lee YR;Huang KJ
通讯作者：
Huang KJ
影响因子：
7
作者：
Muniraj, Nethaji;Siddharth, Sumit;Sharma, Dipali
通讯作者：
Sharma, Dipali
影响因子：
5.6
作者：
Rajendran, Peramaiyan;Li, Feng;Sethi, Gautam
通讯作者：
Sethi, Gautam
影响因子：
11.4
作者：
Mrozek, Krzysztof;Eisfeld, Ann-Kathrin;Bloomfield, Clara D.
通讯作者：
Bloomfield, Clara D.