Mechanism of action of glycyrrhizic acid in inhibition of Epstein-Barr virus replication in vitro
Mechanism of action of glycyrrhizic acid in inhibition of Epstein-Barr virus replication in vitro
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DOI：
10.1016/s0166-3542(03)00030-5
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发表时间：
2003-06-01
影响因子：
7.6
通讯作者：
Lin, JC
中科院分区：
文献类型：
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作者：
Lin, JC
我们在这里报告，甘草酸（GL），甘草根（甘草根）的组成部分，是积极的对EBV复制在超感染的Raji细胞中的剂量依赖性的方式。病毒抑制和细胞生长的IC50值分别为0.04和4.8 mM。选择性指数（细胞生长的IC50与病毒DNA合成的IC50之比）为120。添加时间实验表明，GL干扰EBV复制周期的早期步骤（可能是渗透）。GL对病毒吸附无影响，对EBV颗粒亦无抑制作用。因此，GL代表了一类新的抗EBV化合物，其作用模式不同于抑制病毒DNA聚合酶的核苷类似物。(C)2003 Elsevier Science B.V.保留所有权利。
We report here that glycyrrhizic acid (GL), a component of licorice root (Glycyrrhiza radix), is active against EBV replication in superinfected Raji cells in a dose-dependent fashion. The IC50 values for viral inhibition and cell growth were 0.04 and 4.8 mM, respectively. The selectivity index (ratio of IC50 for cell growth to IC50 for viral DNA synthesis) was 120. Time of addition experiments suggested that GL interferes with an early step of EBV replication cycle (possibly penetration). GL had no effect On viral adsorption, nor did it inactivate EBV particles. Thus, GL represents a new class of anti-EBV compounds with a mode of action different from that of the nucleoside analogs that inhibit viral DNA polymerase. (C) 2003 Elsevier Science B.V. All rights reserved.