Vicinal Functionalization of N-Alkoxyen-amines:Tandem Umpolung Phenylation/Nucleophilic Addition Reaction Sequence
Vicinal Functionalization of N-Alkoxyen-amines:Tandem Umpolung Phenylation/Nucleophilic Addition Reaction Sequence
复制标题
N-烷氧基胺的邻位官能化：串联 Umpolung 苯基化/亲核加成反应序列
DOI：
10.1002/ejoc.201500308
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Masafumi Ueda and Okiko Miyata
中科院分区：
文献类型：
--
作者：
Shohei Sato;Norihiko Takeda;Tetsuya Miyoshi;Masafumi Ueda and Okiko Miyata
由醛和异恶唑烷原位衍生的N-烷氧基烯胺的邻位官能化已经通过利用有机铝试剂和随后的烯丙基溴化镁或三丁基氰化锡作为外部碳中心亲核试剂形成两个新的碳-碳键而实现。通过改变第二碳亲核试剂，以较好的产率得到了各种胺衍生物。
The vicinal functionalization ofN‐alkoxyenamines, derived in situ from aldehydes and isoxazolidines, has been achieved with the formation of two new carbon–carbon bonds by utilizing an organo‐aluminum reagent and subsequent allylmagnesium bromide or tributyltin cyanide as external carbon‐centered nucleophiles. By changing the second carbon nucleophile, various amine derivatives were obtained in good yields.