The Wnt Signalling Pathway: A Tailored Target in Cancer.
The Wnt Signalling Pathway: A Tailored Target in Cancer.
复制标题
Wnt信号通路：癌症中量身定制的靶标。
DOI：
10.3390/ijms21207697
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发表时间：
2020-10-18
影响因子：
5.6
通讯作者：
Brizzi MF
中科院分区：
文献类型：
--
作者：
Koni M;Pinnarò V;Brizzi MF
癌症是最大的公共卫生挑战之一。据世界卫生组织 (WHO) 统计，2018 年有 960 万人因癌症死亡。最常见的癌症包括肺癌、乳腺癌、结直肠癌、前列腺癌、皮肤癌（非黑色素瘤）和胃癌。由于肿瘤细胞突变导致的生理信号通路失衡被认为是最常见的癌症驱动因素。 Wingless 相关整合位点 (Wnt)/β-连环蛋白途径对于所有动物物种的组织发育和体内平衡至关重要，其失调是与癌症发生和传播最相关的事件之一。已知经典和非经典 Wnt/β-catenin 通路可控制生理和病理过程，包括癌症。在此，研究了 Wnt/β-连环蛋白级联在驱动不同来源的癌症中的影响。最后，基于细胞外囊泡（EV）对肿瘤生长、侵袭和化疗耐药的影响，及其作为肿瘤诊断和预后工具的作用，还讨论了将 EV 与 Wnt/β-catenin 通路联系起来的当前知识概述。
Cancer is one of the greatest public health challenges. According to the World Health Organization (WHO), 9.6 million cancer deaths have been reported in 2018. The most common cancers include lung, breast, colorectal, prostate, skin (non-melanoma) and stomach cancer. The unbalance of physiological signalling pathways due to the acquisition of mutations in tumour cells is considered the most common cancer driver. The Wingless-related integration site (Wnt)/β-catenin pathway is crucial for tissue development and homeostasis in all animal species and its dysregulation is one of the most relevant events linked to cancer development and dissemination. The canonical and the non-canonical Wnt/β-catenin pathways are known to control both physiological and pathological processes, including cancer. Herein, the impact of the Wnt/β-catenin cascade in driving cancers from different origin has been examined. Finally, based on the impact of Extracellular Vesicles (EVs) on tumour growth, invasion and chemoresistance, and their role as tumour diagnostic and prognostic tools, an overview of the current knowledge linking EVs to the Wnt/β-catenin pathway is also discussed.
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影响因子：
5.3
作者：
Deng, Minzi;Chen, Zhihong;Liu, Heli
通讯作者：
Liu, Heli
影响因子：
11.2
作者：
Borcherding N;Kusner D;Kolb R;Xie Q;Li W;Yuan F;Velez G;Askeland R;Weigel RJ;Zhang W
通讯作者：
Zhang W
影响因子：
4.4
作者：
Bergenfelz, Caroline;Medrek, Catharina;Leandersson, Karin
通讯作者：
Leandersson, Karin
影响因子：
4
作者：
Berger, Hanna;Breuer, Marlen;Borchers, Annette
通讯作者：
Borchers, Annette
影响因子：
3.7
作者：
Bergenfelz, C.;Janols, H.;Leandersson, K.
通讯作者：
Leandersson, K.