Tamoxifen-induced severe hypertriglyceridemia and pancreatitis
Tamoxifen-induced severe hypertriglyceridemia and pancreatitis
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DOI：
10.1023/a:1008309613082
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发表时间：
2000-08-01
影响因子：
50.5
通讯作者：
Pavlidis, NA
中科院分区：
文献类型：
--
作者：
Elisaf, MS;Nakou, K;Pavlidis, NA
他莫昔芬降低总胆固醇和低密度脂蛋白水平以及脂蛋白(A)水平，因此对血脂和脂蛋白谱有良好的影响。此外，服用他莫昔芬后，血清甘油三酯通常会有少量增加。然而，严重的高甘油三酯血症，有时可能与危及生命的并发症有关，有时会被注意到。在这里，我们描述了一个病人谁发展他莫昔芬诱导的严重高甘油三酯血症和胰腺炎。文中还分析了其潜在的致病机制，并对相关文献进行了综述。
Tamoxifen exhibits favorable effects on the lipid and lipoprotein profile since it decreases the total and LDL cholesterol levels as well as the Lp(a) levels. Additionally, a small increase in serum triglycerides is commonly found after tamoxifen administration. However, severe hypertriglyceridemia which can sometimes be associated with life-threatening complications is occasionally noticed. Herein, we describe a patient who developed tamoxifen-induced severe hypertriglyceridemia and pancreatitis. An analysis of the underlying pathogenetic mechanisms as well as a review of the relevant literature is also provided.