Conversion of α-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women
Conversion of α-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women
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DOI：
10.1016/s0952-3278(03)00111-x
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发表时间：
2003-10-01
影响因子：
3
通讯作者：
Wootton, SA
中科院分区：
文献类型：
--
作者：
Burdge, GC;Wootton, SA
本研究的目的是确定成年人是否可以将α-亚麻酸（18：3 n-3）中的碳再循环为饱和（SFA）和单不饱和（MUFA）脂肪酸。6名男性和6名女性服用了700 mg [U-C-13]-18：3 n-3。在21天内收集血液，在24小时内收集呼吸。在血浆磷脂酰胆碱（PC）和三酰甘油（TAG）中检测到[C-13]标记的SFA和MUFA。总标记的脂肪酸纳入SFA和MUFA是5倍和25倍以上的PC比TAG在男性和女性，分别。[C-13]-16：0是两个馏分中的主要标记脂肪酸。男性SFA和MUFA中的总[C-13]掺入量比女性高20%，并且与呼吸中标记的18：3 n-3作为（CO2）-C-13的回收分数呈正相关（r（2）= 0.35，P < 0.05）。这些结果表明，分配到β-氧化和碳循环的程度可能会调节18：3 n-3转化为长链脂肪酸的可用性。(C)2003 Elsevier Ltd.保留所有权利。
The purpose of this study was to determine whether adult humans can recycle carbon from alpha-linolenic acid (18:3n-3) into saturated (SFA) and monounsaturated (MUFA) fatty acids. Six men and six women consumed 700 mg [U-C-13]-18:3n-3. Blood was collected over 21 days and breath over 24 h. [C-13]-labelled SFA and MUFA were detected in plasma phosphatidylcholine (PC) and triacylglycerol (TAG). Total labelled fatty acid incorporation into SFA and MUFA was five- and 25-fold greater in PC than TAG in men and women, respectively. [C-13]-16:0 was the major labelled fatty acid in both fractions. Total [C-13] incorporation into SFA and MUFA was 20% greater in men than women, and related positively (r(2) = 0.35, P < 0.05) to the fractional recovery of labelled 18:3n-3 as (CO2)-C-13 on breath. These results suggest that the extent of partitioning towards beta-oxidation and carbon recycling may regulate the availability of 18:3n-3 for conversion to longer-chain fatty acids. (C) 2003 Elsevier Ltd. All rights reserved.