Anaplastic ganglioglioma of the cerebellopontine angle - Case report
Anaplastic ganglioglioma of the cerebellopontine angle - Case report
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DOI：
10.2176/nmc.45.591
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发表时间：
2005-11-01
影响因子：
1.9
通讯作者：
Nagahiro, S
中科院分区：
文献类型：
--
作者：
Matsuzaki, K;Uno, M;Nagahiro, S
一位64岁的女性，在右侧桥小脑角有一个罕见的间变性神经节细胞胶质瘤，表现为持续2周的头晕。术前磁振造影显示右侧桥小脑角有一部分强化的囊状病灶。肿瘤通过右侧枕下颅骨切除术次全切除。肿瘤被认为起源于脑干，外生性生长到右侧桥小脑角。组织学检查显示肿瘤性神经节和神经胶质细胞具有间变性特征，如有丝分裂、多形性和内皮细胞增殖。MIB-1标记指数为40%~ 60%。诊断为间变性神经节细胞胶质瘤（世界卫生组织IV级）。她接受了术后放疗，但在术后11个月死于肿瘤复发伴呼吸衰竭。神经节神经胶质瘤通常预后良好。间变性的组织学特征和高MIB-1标记指数可预测不良的临床结局。
A 64-year-old woman presented with a rare anaplastic ganglioglioma in the right cerebellopontine angle manifesting as dizziness persisting for 2 weeks. Preoperative magnetic resonance (MR) imaging revealed a partially enhanced cystic lesion of the right cerebellopontine angle. The tumor was subtotally removed through a right lateral suboccipital craniectomy. The tumor was thought to originate from the brain stem with exophytic growth into the right cerebellopontine angle. Histological examination showed neoplastic ganglional and glial cells with anaplastic features such as mitosis, pleomorphism, and endothelial proliferation. The MIB-1 labeling index of the glial components was 40% to 60%. The diagnosis was anaplastic ganglioglioma (World Health Organization grade IV). She received postoperative radiotherapy but died of respiratory failure with tumor recurrence 11 months after the operation. Gangliogliomas usually have a good prognosis. Histological features of anaplasia and a high MIB-1 labeling index may be predictive of a poor clinical outcome.