Algal toxin impairs sea lion memory and hippocampal connectivity, with implications for strandings
Algal toxin impairs sea lion memory and hippocampal connectivity, with implications for strandings
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DOI：
10.1126/science.aac5675
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发表时间：
2015-12-18
期刊：
影响因子：
56.9
通讯作者：
Ranganath, Charan
中科院分区：
文献类型：
--
作者：
Cook, Peter F.;Reichmuth, Colleen;Ranganath, Charan
软骨藻酸（DA）是一种天然存在的神经毒素，已知会伤害海洋动物。产生da的藻华在规模和频率上都在增加。虽然已知长期接触会产生脑损伤，但DA中毒对野生动物行为的影响尚不清楚。我们在大量野生海狮样本中发现，空间记忆缺陷可以通过与自然暴露于DA有关的右背海马损伤程度来预测，并且暴露也会破坏海马-丘脑大脑网络。因为海狮是动态的觅食者，依靠灵活的导航，受损的空间记忆可能会影响野外的生存。
Domoic acid (DA) is a naturally occurring neurotoxin known to harm marine animals. DA-producing algal blooms are increasing in size and frequency. Although chronic exposure is known to produce brain lesions, the influence of DA toxicosis on behavior in wild animals is unknown. We showed, in a large sample of wild sea lions, that spatial memory deficits are predicted by the extent of right dorsal hippocampal lesions related to natural exposure to DA and that exposure also disrupts hippocampal-thalamic brain networks. Because sea lions are dynamic foragers that rely on flexible navigation, impaired spatial memory may affect survival in the wild.