Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract
Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract
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DOI：
10.1038/nm755
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发表时间：
2002-09-01
期刊：
影响因子：
82.9
通讯作者：
Watanabe, M
中科院分区：
文献类型：
--
作者：
Okamoto, R;Yajima, T;Watanabe, M
研究表明，骨髓细胞具有分化成多种细胞类型的潜力。在这里，我们证明骨髓细胞可以重新填充人类胃肠道的上皮细胞。男性供体来源的上皮细胞分布在女性骨髓移植受者胃肠道的各个部位。在移植物抗宿主病或溃疡形成后的上皮再生过程中，供体来源的上皮细胞大量重新填充胃肠道。用人类供体来源的细胞再生胃肠道上皮，表明骨髓来源的细胞在修复严重受损的上皮方面具有潜在的临床应用，不仅在胃肠道，而且在其他组织中。
Studies have shown that bone marrow cells have the potential to differentiate into a variety of cell types. Here we show that bone marrow cells can repopulate the epithelia of the human gastrointestinal tract. Epithelial cells of male donor origin were distributed in every part of the gastrointestinal tract of female bone marrow transplant recipients. Donor-derived epithelial cells substantially repopulated the gastrointestinal tract during epithelial regeneration after graft-versus-host disease or ulcer formation. Regeneration of gastrointestinal epithelia with donor-derived cells in humans shows a potential clinical application of bone marrow-derived cells for repairing severely damaged epithelia, not only in the gastrointestinal tract but also in other tissues.