Leg ulcer in a patient associated with hydroxyurea therapy
Leg ulcer in a patient associated with hydroxyurea therapy
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DOI：
10.1111/j.1365-4632.2004.02450.x
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发表时间：
2006-02-01
影响因子：
3.6
通讯作者：
Goos, M
中科院分区：
文献类型：
--
作者：
Dissemond, J;Hoeft, D;Goos, M
羟基脲是尿素的羟基化衍生物，常用于治疗各种血液疾病。皮肤副作用，如脱发、弥漫性色素沉着过度、脱屑、皮肤和皮下组织萎缩或指甲变化，可在长期使用羟基脲治疗后发生。与羟基脲相关的腿部疼痛性溃疡很少被报道，我们报告了一个52岁的原发性血小板增多症患者在开始使用羟基脲治疗3年后出现腿部疼痛性溃疡。我们决定治疗腿部溃疡后，现代相适应的伤口愈合策略，并继续hydroxyurea治疗，直到完全愈合的ulcus.In结论，皮肤溃疡的腿是一个不良反应，原发性血小板增多症患者在hydroxyurea治疗。治愈并不一定需要停药。因此，治疗师应首先优化保守和系统的伤口愈合策略。如果这些干预措施失败，建议停止羟基脲治疗。
Hydroxyurea is a hydroxylated derivate of urea commonly used in the treatment of various hematologic disorders. Cutaneous side-effects such as alopecia, diffuse hyperpigmentation, scaling, poikiloderma, atrophy of the skin and subcutaneous tissues or nail changes can develop after long-term treatment with hydroxyurea. Painful leg ulcers in association with hydroxyurea have only rarely been reported.We present a report of a 52-year-old patient with essential thrombocythemia suffering from painful leg ulcers 3 years after starting therapy with hydroxyurea. We decided to treat the leg ulcers following a modern phase-adapted wound-healing strategy and continued hydroxyurea therapy until complete healing of the ulcers.In conclusion, cutaneous ulceration of the leg is one adverse effect in patients with essential thrombocythemia during hydroxyurea therapy. Healing does not necessarily require discontinuation of the drug. Therefore, therapists should first optimize a conservative and systematic wound-healing strategy. If these interventions fail, discontinuation of hydroxyurea therapy is advisable.