Gas Chromatography-(Cyclic) Ion Mobility Mass Spectrometry: A Novel Platform for the Discovery of Unknown Per-/Polyfluoroalkyl Substances.
Gas Chromatography-(Cyclic) Ion Mobility Mass Spectrometry: A Novel Platform for the Discovery of Unknown Per-/Polyfluoroalkyl Substances.
复制标题
气相色谱-（循环）离子淌度质谱：发现未知全氟烷基/多氟烷基物质的新平台。
DOI：
10.1021/acs.analchem.2c02325
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发表时间：
2022
影响因子：
7.4
通讯作者：
K. Jobst
中科院分区：
文献类型：
--
作者：
Amber MacNeil;Xiaolei Li;Roshanak Amiri;D. Muir;A. Simpson;M. Simpson;F. Dorman;K. Jobst
自20世纪40年代以来，全氟烷基和多氟烷基物质（PFAS）已广泛用于工业和日常家用产品。它们还在环境中持久存在，并在人类和野生动物体内进行生物累积。尽管存在这些问题，但环境和生物样品中大多数PFAS的身份仍然未知。在这里，我们描述了一种新的循环离子迁移率质谱仪（cIMS），联用气相色谱（GC）大气压化学电离，可以揭示未知PFASs的存在下，他们的质量和碰撞截面（CCS）的比例的基础上。预测的CCS的CA。工业和商业中使用的20，000种化学品表明，CCS值小于其质量的五分之一的大多数化合物是PFAS或多溴阻燃剂。当这个过滤器被应用到GC-cIMS数据收集从一组20个室内灰尘样品，PFAS化合物显示没有事先知道它们的发生。使用SRM 2585，家庭灰尘的标准参考物质，通过比较PFASs检测到的那些（暂定）在以前的研究中确定的这种方法进行验证。用合成标准品确认了先前初步鉴定的氯氟邻苯二甲酰亚胺。该方法还揭示了氯氟正构烷烃的存在，作为一类新兴的“永久化学品”，污染室内环境。
Per- and polyfluoroalkyl substances (PFASs) have been widely used since the 1940s in industry and everyday household products. They also persist in the environment and bioaccumulate in humans and wildlife. Despite these concerns, the identities of most PFASs in environmental and biological samples are unknown. Herein, we describe a novel cyclic ion mobility mass spectrometer (cIMS), hyphenated with gas chromatography (GC) atmospheric pressure chemical ionization, that can reveal the presence of unknown PFASs on the basis of the ratio of their mass and collision cross section (CCS). Prediction of the CCS of ca. 20,000 chemicals used in industry and commerce indicates that most compounds characterized by CCS values that are less than the sum of 100 Å2 and one-fifth of their mass are either PFASs or polybrominated flame retardants. When this filter is applied to GC-cIMS data collected from a set of 20 indoor dust samples, PFAS compounds are revealed without prior knowledge of their occurrence. Validation of this approach was performed using SRM 2585, a standard reference material of household dust, by comparing the PFASs detected with those (tentatively) identified in previous studies. Chlorofluoro phthalimides tentatively identified previously were confirmed with a synthesized standard. The method also reveals the presence of chlorofluoro n-alkanes as an emerging class of "forever chemicals" that contaminate the indoor environment.