Cerebrosides of the Halotolerant Fungus Alternaria raphani Isolated from a Sea Salt Field
Cerebrosides of the Halotolerant Fungus Alternaria raphani Isolated from a Sea Salt Field
复制标题
海盐田耐盐真菌拉氏链格孢的脑苷脂
DOI：
10.1021/np9002299
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发表时间：
2009-09-01
影响因子：
5.1
通讯作者：
Zhu, Weiming
中科院分区：
文献类型：
--
作者：
Wang, Wenliang;Wang, Yi;Zhu, Weiming
In order to search for structurally novel and bioactive natural compounds from marine-derived fungi, a halotolerant fungal strain (THW-18) identified as Alternaria raphani was isolated from sediment collected in the Hongdao sea salt field. From the ethyl acetate extract of Alteniaria raphani, three new cerebrosides, alternarosides A-C (1-3), and a new diketopiperazine alkaloid, alternarosin A (4), together with 15 known compounds were isolated and identified by spectroscopic and chemical methods, as well as X-ray crystal diffraction analysis. Compounds 1-4 showed weak antibacterial activity against Escherichia coli, Bacillus subtilis, and Candida albicans with MIC values ranging from 70 to 400 mu M..
