Advanced quantitative analysis of the sub-retinal pigment epithelial space in recurrent neovascular age-related macular degeneration.
Advanced quantitative analysis of the sub-retinal pigment epithelial space in recurrent neovascular age-related macular degeneration.
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DOI：
10.1371/journal.pone.0186955
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Noda T
中科院分区：
文献类型：
--
作者：
Sasaki M;Kato Y;Fujinami K;Hirakata T;Tsunoda K;Watanabe K;Akiyama K;Noda T
To quantitatively evaluate changes in the sub-retinal pigment epithelial (RPE) space and determine the association with recurrent neovascular age-related macular degeneration (AMD). Twenty-two eyes treated with intravitreal aflibercept for treatment-naïve neovascular AMD were studied retrospectively. The sub-RPE area, volume, and central retinal thickness (CRT) were evaluated 1 and 2 months after the loading phase using spectral-domain optical coherence tomography. Recurrence was defined as newly detected neovascular activity during the 6 months after the loading phase. In eyes with recurrent AMD, the sub-RPE area increased significantly (P = 0.036) from 1 to 2 months after the loading phase and the sub-RPE volume increased marginally (P = 0.06). Subgroup analysis showed significant (P = 0.008 and P = 0.016, respectively) increases in the sub-RPE area and volume in typical AMD. In eyes with no recurrence, no significant changes occurred in the two parameters. No significant CRT changes occurred in eyes with or without a recurrence. A quantitative analysis demonstrated an increased likelihood of the sub-RPE space shortly after the loading phase in eyes with recurrent AMD; no changes occurred in eyes without a recurrence. These early changes in the sub-RPE space could indicate disease activity and are valuable for predicting recurrences of neovascular AMD.
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影响因子：
13.7
作者：
Martin, Daniel F.;Maguire, Maureen G.;Ferris, Frederick L.
通讯作者：
Ferris, Frederick L.
DOI：
10.1097/00006982-200110000-00003
发表时间：
2001-01-01
影响因子：
3.3
作者：
Yannuzzi, LA;Negrao, S;Borodoker, N
通讯作者：
Borodoker, N
影响因子：
13.7
作者：
Schmidt-Erfurth, Ursula;Waldstein, Sebastian M.;Simader, Christian
通讯作者：
Simader, Christian
影响因子：
13.7
作者：
Wykoff, Charles C.;Croft, Daniel E.;Sadda, SriniVas R.
通讯作者：
Sadda, SriniVas R.
影响因子：
3.1
作者：
Parikh, Rajul;Mathai, Annie;Parikh, Shefali;Sekhar, G. Chandra;Thomas, Ravi
通讯作者：
Thomas, Ravi