Endurance Training in Panic Patients: Spiroergometric and Clinical Effects
Endurance Training in Panic Patients: Spiroergometric and Clinical Effects
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恐慌患者的耐力训练：螺旋测力和临床效果
DOI：
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发表时间：
1998
影响因子：
2.5
通讯作者：
E. Rüther
中科院分区：
文献类型：
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作者：
T. Meyer;A. Broocks;B. Bandelow;U. Hillmer;E. Rüther
在进行10周跑步计划之前（n = 38）和之后（n = 10），用自行车肺量计测定惊恐障碍患者的耐力能力，并与未经训练的健康对照受试者进行相同的训练（n = 11）和接受氯丙咪嗪药物治疗（n = 7）或安慰剂治疗（n = 7）的患者进行比较。与对照组相比，惊恐患者在跑步前最大摄氧量（VO2peak）和乳酸浓度为4 mmol/l （PLAC4）时的负荷显著降低。参加跑步计划的患者和健康对照者通过跑步显著改善了PLaC4。两组之间在耐力方面没有发现显著差异，这表明患者和对照组的改善是一样的。在研究结束时（第10周），跑步比安慰剂更有效地改善恐慌症状（班德洛恐慌广场恐惧症量表、汉密尔顿焦虑量表、临床总体印象量表）。氯丙咪嗪治疗优于安慰剂（所有量表）和跑步（仅临床全球印象）。耐力与焦虑评分在基线时没有相关性，在研究期间，健康的改善也与精神病理学测量的变化没有实质性的相关性。研究表明，恐慌患者的耐力下降，而这种能力可以通过训练来提高。基于肺活量测量结果的耐力训练可以提高临床疗效。
Endurance capacity was determined by bicycle spiroergometry in patients with panic disorder before (n = 38) and after (n = 10) a 10 week running program and compared to untrained healthy control subjects carrying out the same training (n = 11) and patients receiving clomipramine drug therapy (n = 7) or placebo (n = 7). Before the running program maximal oxygen uptake (VO2peak) and the workload corresponding to a lactate concentration of 4 mmol/l (PLAC4) were significantly reduced in panic patients compared to controls. Patients in the running program and healthy controls improved PLaC4 significantly by running. No significant differences in endurance gains were found between these groups, showing that patients and controls improved equally. At study termination (week 10) running was more efficient than placebo in improving panic symptoms (Bandelow PanicAgoraphobia Scale, Hamilton Anxiety Scale, Clinical Global Impression Scale). Clomipramine treatment was better than placebo (all scales) and running (only Clinical Global Impression). Endurance capacity did not correlate with anxiety scores at baseline, nor did improvement in fitness substantially correlate with changes in psychopathology measures during the study. Panic patients were shown to have a decreased endurance capacity which can be raised by training. Endurance training based on spiroergometric results gives rise to clinical improvement.