Evaluation of substantivity of hypochlorous acid as an antiplaque agent: A randomized controlled trial
Evaluation of substantivity of hypochlorous acid as an antiplaque agent: A randomized controlled trial
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DOI：
10.1111/idh.12342
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发表时间：
2018-11-01
影响因子：
2.4
通讯作者：
Calderon-Mendoza, J.
中科院分区：
文献类型：
--
作者：
Lafaurie, G. I.;Zaror, C.;Calderon-Mendoza, J.
背景：次氯酸（HOCl）是一种非抗生素抗菌物质，对口腔病原微生物有显著作用。HOCl作为一种抗牙菌斑剂的影响还没有studied.Objective：本研究的目的是评估的直接性HOCl漱口水相比，氯己定（CHX）冲洗和安慰剂。材料和方法：一个双盲随机对照试验，75名参与者进行。使用区组随机化将参与者分为五组：0.025% HOCl，0.05% HOCl，0.12% CHX，0.2% CHX和无菌水作为安慰剂。指导参与者在牙齿预防后使用每种冲洗溶液30秒。在基线和30秒、1、3、5和7小时后采集唾液样本以评估直接性，并通过荧光法确定细菌活力。在基线和7小时时使用Turesky指数评估所有参与者的可见牙菌斑，并评估不良事件。结果：HOCl导致30秒后唾液中的细菌计数减少33%，而CHX减少58%。HOCl无直接性，1小时后细菌计数恢复至基线。与CHX和HOCl组相比，安慰剂治疗导致7小时后最高的空斑计数，尽管差异不显著。HOCl冲洗引起的最高百分比的不愉快的味道和干燥的sensations.Conclusions：HOCl冲洗液对唾液中的细菌活力有初步的影响，但没有直接性。其他机制可以解释其抗斑块作用。
Background: Hypochlorous acid (HOCl) is a non-antibiotic antimicrobial substance with significant effects on pathogenic oral micro-organisms. The effects of HOCl as an antiplaque agent have not been studied.Objective: The aim of this study was to evaluate the substantivity of HOCl mouthwashes compared with chlorhexidine (CHX) rinses and a placebo.Materials and Methods: A double-blind randomized controlled trial with 75 participants was conducted. Participants were divided into five groups using block randomization: 0.025% HOCl, 0.05% HOCl, 0.12% CHX, 0.2% CHX, and sterile water as a placebo. Participants were instructed to use each rinse solution for 30 seconds after dental prophylaxis. Samples of saliva were taken at baseline and after 30 seconds, 1, 3, 5 and 7 hours to assess substantivity, and bacterial viability was established by the fluorescence method. Visible plaque in all participants was assessed with the Turesky index at baseline and at 7 hours, and adverse events were also assessed.Results: HOCl led to a 33% reduction in bacterial counts in the saliva after 30 seconds compared with a 58% reduction by CHX. HOCl has no substantivity, and bacterial counts returned to baseline after 1 hour. Placebo treatment led to the highest plaque count after 7 hours compared with the CHX and HOCl groups, although the differences were not significant. HOCl rinsing induced the highest percentages of unpleasant taste and dryness sensations.Conclusions: HOCl rinses have an initial effect on bacterial viability in saliva but have no substantivity. Other mechanisms may explain its antiplaque effect.