Ni(COD)(DMFU): A Heteroleptic 16-Electron Precatalyst for 1,2-Diarylation of Alkenes
Ni(COD)(DMFU): A Heteroleptic 16-Electron Precatalyst for 1,2-Diarylation of Alkenes
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DOI：
10.1055/a-1344-6040
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发表时间：
2021-01-02
期刊：
影响因子：
2
通讯作者：
Engle, Keary M.
中科院分区：
文献类型：
--
作者：
Kim, Nana;Tran, Van T.;Engle, Keary M.
已知缺电子烯烃（EDO）配体促进多种镍催化的交叉偶联反应，推测是通过加速还原消除步骤和防止不期望的氢化物消除。虽然有越来越多的实验和计算证据阐明EDO配体的有益作用，但我们对所涉及的Ni-EDO物种的潜在配位化学的理解仍存在重大差距。特别地，大多数程序依赖于活性催化剂的原位组装，并且缺乏预连接的Ni-EDO预催化剂。在此，我们研究了16-电子，杂配镍配合物，Ni（COD）（DMFU），并检查该配合物作为预催化剂在烯烃的1，2-二芳基化反应中的性能。
Electron-deficient olefin (EDO) ligands are known to promote a variety of nickel-catalyzed cross-coupling reactions, presumably by accelerating the reductive elimination step and preventing undesired beta-hydride elimination. While there is a growing body of experimental and computational evidence elucidating the beneficial effects of EDO ligands, significant gaps remain in our understanding of the underlying coordination chemistry of the Ni-EDO species involved. In particular, most procedures rely on in situ assembly of the active catalyst, and there is a paucity of preligated Ni-EDO precatalysts. Herein, we investigate the 16-electron, heteroleptic nickel complex, Ni(COD)(DMFU), and examine the performance of this complex as a precatalyst in 1,2-diarylation of alkenes.