STUDIES ON MECHANISM OF ACTION OF GLYCYRRHIZIN AGAINST HEPATITIS-A VIRUS-REPLICATION IN-VITRO
STUDIES ON MECHANISM OF ACTION OF GLYCYRRHIZIN AGAINST HEPATITIS-A VIRUS-REPLICATION IN-VITRO
复制标题
DOI：
10.1016/0166-3542(94)90033-7
复制
发表时间：
1994-01-01
影响因子：
7.6
通讯作者：
DELOINCE, R
中科院分区：
文献类型：
--
作者：
CRANCE, JM;LEVEQUE, F;DELOINCE, R
甘草甜素（GL）对甲型肝炎病毒（HAV）在PLC/PRF/5细胞中的复制具有浓度依赖性的抑制作用。GL已显示抑制HAV复制的早期阶段。GL不具有杀病毒性，对[H-3]尿苷标记的病毒粒子吸附至细胞没有可测量的影响。GL可抑制HAV穿透质膜，通过测定感染性病毒的量（随着时间的推移，不再被特异性抗体中和）来测定。
Glycyrrhizin (GL) achieved a concentration-dependent inhibition of the replication of hepatitis A virus (HAV) in PLC/PRF/5 cells. GL has been shown to inhibit an early stage of the HAV replication. GL was not virucidal and had no measurable effect on the adsorption of [H-3]uridine-labelled virions to cells. GL inhibited HAV penetration of the plasma membrane as measured by the amount of infective virus no longer neutralizable by specific antibody over time.