Toward the Next Generation of Negative Symptom Assessments: The Collaboration to Advance Negative Symptom Assessment in Schizophrenia
Toward the Next Generation of Negative Symptom Assessments: The Collaboration to Advance Negative Symptom Assessment in Schizophrenia
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DOI：
10.1093/schbul/sbq104
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发表时间：
2011-03-01
影响因子：
6.6
通讯作者：
Gur, Raquel
中科院分区：
文献类型：
--
作者：
Blanchard, Jack J.;Kring, Ann M.;Gur, Raquel
精神分裂症的阴性症状与不良的功能结局有关，随着时间的推移持续存在，是照顾者的负担来源，并且对目前可用的药物只有最低限度的反应。制定有效干预措施的一个主要挑战是对阴性症状进行有效和可靠的评估。在最近关于阴性症状的共识声明中，一项核心建议是需要制定新的评估方法，以解决现有工具的局限性。在本报告中，我们总结了精神分裂症阴性症状评估协作组（CANSAS）的背景和基本原理。CANSAS项目是一项由美国国家心理健康研究所资助的多地点研究，正在构建下一代阴性症状量表，阴性症状临床评估访谈（CAINS）。CAINS是在一个数据驱动的迭代过程中开发的，该过程旨在确保测量的可靠性，有效性和实用性，用于基础精神病理学和治疗开发研究。
Negative symptoms in schizophrenia are related to poor functional outcome, persistent over time, a source of burden for caregivers, and only minimally responsive to currently available medications. A major challenge to developing efficacious interventions concerns the valid and reliable assessment of negative symptoms. In a recent consensus statement on negative symptoms, a central recommendation was the need to develop new assessment approaches that address the limitations of existing instruments. In the current report, we summarize the background and rationale for the Collaboration to Advance Negative Symptom Assessment in Schizophrenia (CANSAS). The CANSAS project is an National Institute of Mental Health-funded multisite study that is constructing a next-generation negative symptom scale, the Clinical Assessment Interview for Negative Symptoms (CAINS). The CAINS is being developed within a data-driven iterative process that seeks to ensure the measure's reliability, validity, and utility for both basic psychopathology and treatment development research.