Time restricted feeding decreases renal innate immune cells and blood pressure in hypertensive mice.
Time restricted feeding decreases renal innate immune cells and blood pressure in hypertensive mice.
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DOI：
10.1097/hjh.0000000000003200
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发表时间：
2022-10-01
影响因子：
4.9
通讯作者：
中科院分区：
文献类型：
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肾脏先天免疫细胞积聚和炎症与高血压有关。据报道，限时喂养（TRF）可以减少炎症和血压。 TRF是否可以通过减少高血压患者的肾脏先天免疫细胞来降低血压尚不清楚。我们确定了 TRF 是否可以降低两种不同的高血压小鼠模型：N(G)-硝基-L-精氨酸甲酯盐酸盐诱导的高血压 (LHTN) 和盐敏感性高血压 (SSHTN) 的血压。 2 天后一旦形成高血压，持续 4 周的 TRF（12 小时进食/12 小时不进食）可显着降低 LHTN 和 SSHTN 小鼠的收缩压，尽管各组之间的进食量或体重没有差异。在接受 TRF 的小鼠中，LHTN 和 SSHTN 小鼠肾脏中活化的巨噬细胞和树突状细胞显着减少。这与肾功能的改善（血清肌酐降低、钠排泄分数减少和肌酐清除率增加）相关，这在 LHTN 小鼠中具有显着意义，并且在 SSHTN 小鼠中呈改善趋势。我们的研究结果表明，TRF 可以显着降低两种高血压小鼠模型的肾脏先天免疫细胞和血压。
Renal innate immune cell accumulation and inflammation are associated with hypertension. Time restricted feeding (TRF) has been reported to decrease inflammation and blood pressure. Whether TRF can decrease blood pressure by decreasing renal innate immune cells in hypertension is unknown. We determined whether TRF can decrease blood pressure in two separate mouse models of hypertension, N(G)-nitro-L-arginine methyl ester hydrochloride-induced hypertension (LHTN) and salt-sensitive hypertension (SSHTN). Once hypertension was established after 2 days, TRF (12-h food/12-h no food) for 4 weeks significantly decreased systolic blood pressure in both LHTN and SSHTN mice despite no differences in the amount of food eaten or body weight between groups. Activated macrophages and dendritic cells in the kidneys of both LHTN and SSHTN mice were decreased significantly in mice that underwent TRF. This was associated with an improvement in kidney function (decreased serum creatinine, decreased fractional excretion of sodium, and increased creatinine clearance) which achieved significance in LHTN mice and trended towards improvement in SSHTN mice. Our findings demonstrate that TRF can significantly decrease renal innate immune cells and blood pressure in two mouse models of hypertension.